Regulation of SARS-CoV-2 infection and antiviral innate immunity by ubiquitination and ubiquitin-like conjugation

IF 2.6 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimica et Biophysica Acta-Gene Regulatory Mechanisms Pub Date : 2023-09-17 DOI:10.1016/j.bbagrm.2023.194984

Yi Zheng , Huiyu Yang , Xuejing Zhang , Chengjiang Gao

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引用次数: 0

Abstract

A global pandemic COVID-19 resulting from SARS-CoV-2 has affected a significant portion of the human population. Antiviral innate immunity is critical for controlling and eliminating the viral infection. Ubiquitination is extensively involved in antiviral signaling, and recent studies suggest that ubiquitin-like proteins (Ubls) modifications also participate in innate antiviral pathways such as RLR and cGAS-STING pathways. Notably, virus infection harnesses ubiquitination and Ubls modifications to facilitate viral replication and counteract innate antiviral immunity. These observations indicate that ubiquitination and Ubls modifications are critical checkpoints for the tug-of-war between virus and host. This review discusses the current progress regarding the modulation of the SARS-CoV-2 life cycle and antiviral innate immune pathways by ubiquitination and Ubls modifications. This paper emphasizes the arising concept that ubiquitination and Ubls modifications are powerful modulators of virus and host interaction and potential drug targets for treating the infection of SARS-CoV-2.

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通过泛素化和泛素样结合调节严重急性呼吸系统综合征冠状病毒2型感染和抗病毒先天免疫。

由严重急性呼吸系统综合征冠状病毒2型引起的全球大流行新冠肺炎影响了相当一部分人口。抗病毒先天免疫对于控制和消除病毒感染至关重要。泛素化广泛参与抗病毒信号传导，最近的研究表明，泛素样蛋白（Ubls）修饰也参与先天抗病毒途径，如RLR和cGAS-STING途径。值得注意的是，病毒感染利用泛素化和Ubls修饰来促进病毒复制并对抗先天抗病毒免疫。这些观察结果表明，泛素化和Ubls修饰是病毒和宿主之间拉锯战的关键检查点。这篇综述讨论了通过泛素化和Ubls修饰调节严重急性呼吸系统综合征冠状病毒2型生命周期和抗病毒先天免疫途径的最新进展。本文强调了一个新概念，即泛素化和Ubls修饰是病毒和宿主相互作用的强大调节剂，也是治疗严重急性呼吸系统综合征冠状病毒2型感染的潜在药物靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochimica et Biophysica Acta-Gene Regulatory Mechanisms 生物-生化与分子生物学

CiteScore

9.20

自引率

2.10%

发文量

审稿时长

44 days

期刊介绍： BBA Gene Regulatory Mechanisms includes reports that describe novel insights into mechanisms of transcriptional, post-transcriptional and translational gene regulation. Special emphasis is placed on papers that identify epigenetic mechanisms of gene regulation, including chromatin, modification, and remodeling. This section also encompasses mechanistic studies of regulatory proteins and protein complexes; regulatory or mechanistic aspects of RNA processing; regulation of expression by small RNAs; genomic analysis of gene expression patterns; and modeling of gene regulatory pathways. Papers describing gene promoters, enhancers, silencers or other regulatory DNA regions must incorporate significant functions studies.