High-Density (HD) Scalp EEG Findings in "Benign" Childhood Epilepsy with Centrotemporal Spikes (BCECTS).

IF 1.6 4区 医学 Q3 CLINICAL NEUROLOGY
Clinical EEG and Neuroscience Pub Date : 2024-03-01 Epub Date: 2022-12-14 DOI:10.1177/15500594221145265
Sonal Bhatia, Andrew Todd Ham, Ekrem Kutluay
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引用次数: 0

Abstract

Despite characteristic clinical and scalp EEG findings, BCECTS pathophysiology is unclear regarding involvement of large-scale neuronal networks. Higher number of scalp electrodes with HD-EEG may promote accurate localization of the cortical generators in BCECTS providing additional insight in those with neurocognitive problems. We aimed to determine the value of visual interpretation of topographical maps using 256 channels (when compared to standard 21 channel array) HD-EEG in BCECTS and attempted to source localize interictal discharges (IEDs) using Geosource 2 software. Patient records were reviewed for demographic, seizure, brain magnetic resonance imaging (MRI) details; scalp and HD-EEG findings. HD-EEG software was used to review raw EEG data (21 scalp EEG electrodes were compared to 256 HD-EEG electrodes); select, average, and source localize IEDs.Five BCECTS patients with HD-EEG were identified. Seizure onset age ranged from 5-11 years with 1-18 lifetime seizures; both focal (n = 3) and focal to bilateral tonic-clonic (n = 2). Neurocognitive co-morbidities noted in our cohort included attention deficit hyperactivity disorder, speech/developmental delay and a specific learning disorder. Scalp EEG showed typical findings with IEDs over the centrotemporal regions (bilateral n = 3; unilateral n = 2). Visualization and inspection of expanded coverage topographic maps with HD-EEG showed well-defined islands of maximum negativity and positivity of a dipole compared to conventional channels where boundary delineation was obscured. Further, HD-EEG localized IEDs/"spike-generator" to areas such as the pre-and post-central, middle-frontal and temporal gyrus, and the inferior parietal lobule. In BCECTS, HD-EEG may show affection for a broader neural network and may provide a better insight into the associated neurocognitive morbidities.

颞叶中心棘波 "良性 "儿童癫痫 (BCECTS) 的高密度 (HD) 头皮脑电图结果。
尽管有特征性的临床和头皮脑电图发现,但 BCECTS 的病理生理学还不清楚大规模神经元网络的参与情况。使用 HD-EEG 的更多头皮电极可能会促进 BCECTS 中皮质发生器的准确定位,从而为有神经认知问题的患者提供更多的洞察力。我们旨在确定在 BCECTS 中使用 256 通道(与标准 21 通道阵列相比)HD-EEG 可视化解读地形图的价值,并尝试使用 Geosource 2 软件对发作间期放电 (IED) 进行源定位。对患者病历中的人口统计学、癫痫发作、脑磁共振成像 (MRI) 详情、头皮和 HD-EEG 结果进行了审查。使用 HD-EEG 软件查看原始脑电图数据(将 21 个头皮脑电图电极与 256 个 HD-EEG 电极进行比较);选择、平均和源定位 IED。癫痫发作的发病年龄为 5-11 岁,终生癫痫发作次数为 1-18 次;既有局灶性癫痫发作(3 次),也有局灶性至双侧强直阵挛性癫痫发作(2 次)。本组患者的神经认知并发症包括注意力缺陷多动障碍、言语/发育迟缓和特殊学习障碍。头皮脑电图显示典型的颞中区IED(双侧n = 3;单侧n = 2)。使用 HD-EEG 对扩大覆盖范围的地形图进行观察和检查后发现,与边界划分不清的传统通道相比,偶极子的最大负性和正性岛清晰明确。此外,HD-EEG 还将 IED/"尖峰发生器 "定位在中央前回和中央后回、额叶中回和颞叶以及顶叶下回等区域。在 BCECTS 中,HD-EEG 可能会显示出更广泛的神经网络,并能更好地了解相关的神经认知病症。
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来源期刊
Clinical EEG and Neuroscience
Clinical EEG and Neuroscience 医学-临床神经学
CiteScore
5.20
自引率
5.00%
发文量
66
审稿时长
>12 weeks
期刊介绍: Clinical EEG and Neuroscience conveys clinically relevant research and development in electroencephalography and neuroscience. Original articles on any aspect of clinical neurophysiology or related work in allied fields are invited for publication.
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