COMPARATIVE EVALUATION OF SKIN SUTURE IN RATS WITH POLYGLYCAPRONE 25 AND NYLON.

IF 0.5 4区医学 Q4 ORTHOPEDICS

Acta Ortopedica Brasileira Pub Date : 2023-01-01 DOI:10.1590/1413-785220233104e266635

Rafael Saleme Alves, Leonardo Yabu Tanaka, Victor Bignatto Carvalho, Leticia Candido Lopes, Sofia Brandão Dos Santos, Nuha Ahmad Dsouki, Bruno Fiorelini Pereira, Monica Akemi Sato

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Abstract

Currently, the market offers a wide variety of suture threads, made of materials with different structural and chemical properties. Among many other characteristics, they vary in origin, absorption or degradation, and structure. From this variety, the clinical doubt arises as to which material provides the patient with the best healing quality.

Objective: This study aims to comparatively evaluate two different types of suture threads-Monocryl^® (polyglycaprone 25) and Ethilon^® (nylon)-regarding their ability to aid in tissue regeneration by a histological and immunohistochemical analysis of the skin of rats sutured with the aforementioned materials.

Methods: This basic experimental study used 12 adult Wistar rats, randomly divided into three groups with four animals each and subjected to four longitudinal incisions under anesthesia. Each group corresponded to a postsurgical evaluation date (one, seven, and 14 days).

Results: At 14 postoperative days, the studied groups had no histological difference. However, the use of nylon thread showed greater evidence of earlier fibrotic union.

Conclusion: This study found no histological difference in healing 14 days after surgery among the techniques and the types of suture threads. Level of Evidence II, Therapeutic Studies.

Abstract Image

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聚乙二醇25与尼龙对大鼠皮肤缝合效果的比较评价。

目前，市场上提供各种各样的缝合线，由不同结构和化学性质的材料制成。在许多其他特征中，它们在起源、吸收或降解和结构上各不相同。从这些不同的材料中，临床出现了关于哪种材料能给病人提供最好的愈合质量的疑问。目的:本研究旨在通过对用上述材料缝合的大鼠皮肤进行组织学和免疫组织化学分析，比较评估两种不同类型的缝线- monocryl®(聚甘油25)和Ethilon®(尼龙)-对组织再生的帮助能力。方法:本基础实验选用12只成年Wistar大鼠，随机分为3组，每组4只，麻醉下行4个纵向切口。每组对应于术后评估日期(1、7和14天)。结果:术后14天，各组无组织学差异。然而，尼龙线的使用显示了更早纤维化愈合的证据。结论:不同缝线方式和缝线类型对术后14天愈合无组织学差异。证据水平II，治疗性研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Ortopedica Brasileira Orthopedics-

CiteScore

0.90

自引率

14.30%

发文量

审稿时长

25 weeks

期刊介绍： A Revista Acta Ortopédica Brasileira, órgão oficial do Departamento de Ortopedia e Traumatologia da Faculdade de Medicina da Universidade de São Paulo (DOT/FMUSP), é publicada bimestralmente em seis edições ao ano (jan/fev, mar/abr, maio/jun, jul/ago, set/out e nov/dez) com versão em inglês disponível nos principais indexadores nacionais e internacionais e instituições de ensino do Brasil. Sendo hoje reconhecidamente uma importante contribuição para os especialistas da área com sua seriedade e árduo trabalho para as indexações já conquistadas.