{"title":"Chemical-Physical Mechanisms of Adsorption for Blood Purification.","authors":"Sabrina Copelli, Anna Lorenzin, Claudio Ronco","doi":"10.1159/000529402","DOIUrl":null,"url":null,"abstract":"<p><p>The removal of soluble toxins from blood is necessary in patients with severe kidney failure. The majority of blood purification techniques are based on the use of semipermeable membranes, such as for dialysis treatment. But, whenever there is the need to remove small soluble molecules from blood, the use of such purification techniques may exhibit limited efficiency. This leads to a search for better-performing treatments. Hemoperfusion, given the recent strong advances in the sorption media biocompatibility with plasma (or blood), is considered a promising blood purification technique. This introductive chapter aims at briefly presenting the phenomenology of the adsorption process, also providing some basic elements related to how to use equilibrium load data to define an adsorption isotherm, which can be used to size a hemoperfusion cartridge.</p>","PeriodicalId":10725,"journal":{"name":"Contributions to nephrology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Contributions to nephrology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000529402","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/5/22 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
The removal of soluble toxins from blood is necessary in patients with severe kidney failure. The majority of blood purification techniques are based on the use of semipermeable membranes, such as for dialysis treatment. But, whenever there is the need to remove small soluble molecules from blood, the use of such purification techniques may exhibit limited efficiency. This leads to a search for better-performing treatments. Hemoperfusion, given the recent strong advances in the sorption media biocompatibility with plasma (or blood), is considered a promising blood purification technique. This introductive chapter aims at briefly presenting the phenomenology of the adsorption process, also providing some basic elements related to how to use equilibrium load data to define an adsorption isotherm, which can be used to size a hemoperfusion cartridge.
期刊介绍：
The speed of developments in nephrology has been fueled by the promise that new findings may improve the care of patients suffering from renal disease. Participating in these rapid advances, this series has released an exceptional number of volumes that explore problems of immediate importance for clinical nephrology. Focus ranges from discussion of innovative treatment strategies to critical evaluations of investigative methodology. The value of regularly consolidating the newest findings and theories is enhanced through the inclusion of extensive bibliographies which make each volume a reference work deserving careful study.
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