The association between prenatal famine, DNA methylation and mental disorders: a systematic review and meta-analysis.

IF 5.7 2区 医学 Q1 Medicine
Heike Eichenauer, Ulrike Ehlert
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引用次数: 0

Abstract

Background: Undernutrition in pregnant women is an unfavorable environmental condition that can affect the intrauterine development via epigenetic mechanisms and thus have long-lasting detrimental consequences for the mental health of the offspring later in life. One epigenetic mechanism that has been associated with mental disorders and undernutrition is alterations in DNA methylation. The effect of prenatal undernutrition on the mental health of adult offspring can be analyzed through quasi-experimental studies such as famine studies. The present systematic review and meta-analysis aims to analyze the association between prenatal famine exposure, DNA methylation, and mental disorders in adult offspring. We further investigate whether altered DNA methylation as a result of prenatal famine exposure is prospectively linked to mental disorders.

Methods: We conducted a systematic search of the databases PubMed and PsycINFO to identify relevant records up to September 2022 on offspring whose mothers experienced famine directly before and/or during pregnancy, examining the impact of prenatal famine exposure on the offspring's DNA methylation and/or mental disorders or symptoms.

Results: The systematic review showed that adults who were prenatally exposed to famine had an increased risk of schizophrenia and depression. Several studies reported an association between prenatal famine exposure and hyper- or hypomethylation of specific genes. The largest number of studies reported differences in DNA methylation of the IGF2 gene. Altered DNA methylation of the DUSP22 gene mediated the association between prenatal famine exposure and schizophrenia in adult offspring. Meta-analysis confirmed the increased risk of schizophrenia following prenatal famine exposure. For DNA methylation, meta-analysis was not suitable due to different microarrays/data processing approaches and/or unavailable data.

Conclusion: Prenatal famine exposure is associated with an increased risk of mental disorders and DNA methylation changes. The findings suggest that changes in DNA methylation of genes involved in neuronal, neuroendocrine, and immune processes may be a mechanism that promotes the development of mental disorders such as schizophrenia and depression in adult offspring. Such findings are crucial given that undernutrition has risen worldwide, increasing the risk of famine and thus also of negative effects on mental health.

Abstract Image

Abstract Image

产前饥荒、DNA甲基化与精神障碍之间的关系:一项系统综述和荟萃分析。
背景:孕妇营养不足是一种不利的环境条件,可通过表观遗传学机制影响宫内发育,从而对后代日后的心理健康产生长期不利影响。一种与精神障碍和营养不良相关的表观遗传学机制是DNA甲基化的改变。产前营养不良对成年子女心理健康的影响可以通过饥荒研究等准实验研究来分析。本系统综述和荟萃分析旨在分析产前饥荒暴露、DNA甲基化和成年后代精神障碍之间的关系。我们进一步研究了产前饥荒暴露导致的DNA甲基化改变是否与精神障碍有前瞻性联系。方法:我们对PubMed和PsycINFO数据库进行了系统搜索,以确定截至2022年9月,母亲在怀孕前和/或怀孕期间直接经历饥荒的后代的相关记录,检查产前饥荒暴露对后代DNA甲基化和/或精神障碍或症状的影响。结果:系统综述显示,产前接触饥荒的成年人患精神分裂症和抑郁症的风险增加。几项研究报告了产前饥荒暴露与特定基因的高甲基化或低甲基化之间的联系。报道IGF2基因DNA甲基化差异的研究数量最多。DUSP22基因DNA甲基化的改变介导了成年后代产前饥荒暴露与精神分裂症之间的关系。荟萃分析证实产前饥荒暴露后精神分裂症的风险增加。对于DNA甲基化,由于微阵列/数据处理方法不同和/或数据不可用,荟萃分析不适用。结论:产前饥荒暴露与精神障碍和DNA甲基化变化的风险增加有关。研究结果表明,参与神经元、神经内分泌和免疫过程的基因DNA甲基化的变化可能是促进成年后代精神分裂症和抑郁症等精神障碍发展的机制。鉴于营养不良在全球范围内加剧,增加了饥荒的风险,从而也对心理健康产生了负面影响,这些发现至关重要。
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来源期刊
Clinical Epigenetics
Clinical Epigenetics Biochemistry, Genetics and Molecular Biology-Developmental Biology
CiteScore
8.90
自引率
5.30%
发文量
150
审稿时长
12 weeks
期刊介绍: Clinical Epigenetics, the official journal of the Clinical Epigenetics Society, is an open access, peer-reviewed journal that encompasses all aspects of epigenetic principles and mechanisms in relation to human disease, diagnosis and therapy. Clinical trials and research in disease model organisms are particularly welcome.
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