Optical biometric measurements in patients with previous COVID-19 treatment.

IF 0.2 Q4 OPHTHALMOLOGY

Spektrum der Augenheilkunde Pub Date : 2022-07-26 DOI:10.1007/s00717-022-00526-9

Tugba Çetinkaya, Muhammed Mustafa Kurt

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引用次数: 0

Abstract

Background: We aimed to compare optical biometric measurements using optical biometry in patients with previously received COVID-19 treatment and a control group.

Methods: In this cross-sectional study, patients with previously received COVID-19 treatment formed the COVID-19 group and age- and sex-matched healthy participants formed the control group. Optical biometric measurements including keratometry, corneal astigmatism, astigmatic axis, central corneal thickness, anterior chamber depth, and axial length were made using a Nidek optical biometer (AL-Scan; Nidek Co., Ltd., Japan).

Results: Measurements of keratometry (p = 0.79), corneal astigmatism (p = 0.41), axial length (p = 0.96), anterior chamber depth (p = 0.59), and central corneal thickness (p = 0.37) were similar between the COVID-19 and control groups. The astigmatic axis type taken from 2.4 mm of the cornea showed significant difference between the two groups (p = 0.02, χ²), while the measurements taken from 3.3 mm of the cornea were similar (p = 0.10, χ²). In the subgroup analysis, axial length, anterior chamber depth, and central corneal thickness measurements were found to be statistically significantly higher in male patients of the COVID-19 group (p = 0.02; p = 0.001; p = 0.02, t test).

Conclusion: The changes in optical biometric measurements found in our study were due to the fact that COVID-19 is more frequent and severe in males, SARS-CoV‑2 can attach to the cornea via ACE‑2 receptors, and favipiravir can reach the aqueous humor. To our knowledge, there is no study on this subject to date, and therefore more research is needed to shed light on this topic.

Abstract Image

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对曾接受过 COVID-19 治疗的患者进行光学生物测量。

背景：我们的目的是比较曾接受过COVID-19治疗的患者和对照组的光学生物计量学测量结果：在这项横断面研究中，曾接受过 COVID-19 治疗的患者组成 COVID-19 组，年龄和性别匹配的健康参与者组成对照组。使用 Nidek 光学生物测量仪（AL-Scan；日本 Nidek 公司）进行光学生物测量，包括角膜度数、角膜散光、散光轴、角膜中央厚度、前房深度和轴长：结果：COVID-19 组和对照组的角膜度数（p = 0.79）、角膜散光（p = 0.41）、轴长（p = 0.96）、前房深度（p = 0.59）和中央角膜厚度（p = 0.37）的测量结果相似。从角膜 2.4 毫米处测量的散光轴类型在两组之间有显著差异（p = 0.02，χ2），而从角膜 3.3 毫米处测量的散光轴类型则相似（p = 0.10，χ2）。在亚组分析中发现，COVID-19 组男性患者的轴长、前房深度和角膜中央厚度测量值在统计学上显著更高（p = 0.02；p = 0.001；p = 0.02，t 检验）：结论：我们的研究中发现的光学生物测量指标的变化是由于 COVID-19 在男性中更为常见和严重，SARS-CoV-2 可通过 ACE-2 受体附着在角膜上，而法非比拉韦可到达房水。据我们所知，迄今为止还没有关于这一主题的研究，因此需要更多的研究来揭示这一主题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Spektrum der Augenheilkunde 医学-眼科学

CiteScore

0.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： "Spektrum der Augenheilkunde" is an educational journal for ophthalmologists. It is published six times per year and presents reviews, original papers, editorials, case studies and analyses surrounding technical innovations in ophthalmology. Letters to the editor, guest commentaries, book reviews, literature overviews, product information and a congress calendar complete the range of its contents. Thus, "Spektrum der Augenheilkunde" keeps ophthalmologists up-to-date on current developments, both practice-relevant and research-related. The editorial board and its editorial advisors guarantee the high quality of publications and a broad, well-balanced choice of published topics. Topics of interest: Complete range of ophthalmology; Ethical standards; Declaration of Helsinki, Informed consent, Animal rights