Efficacy and safety of corticosteroid regimens for the treatment of hospitalized COVID-19 patients: a meta-analysis.

IF 2.1 4区医学 Q3 VIROLOGY

Future Virology Pub Date : 2022-07-01 Epub Date: 2022-06-03 DOI:10.2217/fvl-2021-0244

Fangwen Zhou, Jiawen Deng, Kiyan Heybati, Qi Kang Zuo, Saif Ali, Wenteng Hou, Chi Yi Wong, Harikrishnaa Ba Ramaraju, Oswin Chang, Thanansayan Dhivagaran, Zachary Silver

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引用次数: 0

Abstract

Aim: To evaluate the efficacy and safety of corticosteroids for treating hospitalized COVID-19 patients.

Materials & methods: Efficacy outcomes included time to negative SARS-CoV-2 tests, length of stay, duration and incidence of intensive unit care stay, incidence of mortality and duration and incidence of mechanical ventilation. Safety outcomes included the incidence of adverse events and severe adverse events, incidence of hyperglycemia and incidence of nosocomial infections.

Results: Ninety-five randomized controlled trials (RCTs) and observational studies (n = 42,205) were included. Corticosteroids were associated with increased length of stay (based on RCT only), increased time to negative tests, decreased length of mechanical ventilation and increased odds of hyperglycemia.

Conclusion: Corticosteroids should be considered in patients requiring mechanical ventilation, and glycemic monitoring may be needed when administering corticosteroids.

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治疗 COVID-19 住院患者的皮质类固醇方案的有效性和安全性：一项荟萃分析。

目的：评估皮质类固醇治疗 COVID-19 住院患者的疗效和安全性：疗效指标包括SARS-CoV-2检测阴性时间、住院时间、重症监护室住院时间和发生率、死亡率、机械通气时间和发生率。安全性结果包括不良事件和严重不良事件的发生率、高血糖的发生率以及院内感染的发生率：结果：共纳入 95 项随机对照试验 (RCT) 和观察性研究（n = 42 205）。皮质类固醇与住院时间延长（仅基于随机对照试验）、检测阴性时间延长、机械通气时间缩短和高血糖几率增加有关：结论：需要机械通气的患者应考虑使用皮质类固醇，在使用皮质类固醇时可能需要进行血糖监测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Future Virology 医学-病毒学

CiteScore

4.00

自引率

3.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Future Virology is a peer-reviewed journal that delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this ever-expanding area of research. It is an interdisciplinary forum for all scientists working in the field today.