Opioid relapse and its predictors among methadone maintenance patients: a multicenter, cross-sectional study in Vietnam.

IF 4 2区社会学 Q1 SUBSTANCE ABUSE

Harm Reduction Journal Pub Date : 2023-09-16 DOI:10.1186/s12954-023-00872-0

Huong Thi Thanh Nguyen, Dai Xuan Dinh

{"title":"Opioid relapse and its predictors among methadone maintenance patients: a multicenter, cross-sectional study in Vietnam.","authors":"Huong Thi Thanh Nguyen, Dai Xuan Dinh","doi":"10.1186/s12954-023-00872-0","DOIUrl":null,"url":null,"abstract":"Background: Opioid relapse, one of the common and severe problems during methadone maintenance treatment, can give rise to poor treatment outcomes. This study measured the opioid relapse rate and its associated factors among methadone maintenance patients in Vietnam.Methods: Information about the demographic characteristics and social support of 655 patients was collected through direct interviews. Medical records were used to gather data on treatment characteristics. Relapse was determined via urine opioid test results.Results: The overall relapse rate of patients during treatment was 13.1%. According to the multivariate logistic regression model, living in mountainous areas (adjusted odds ratio (aOR) = 3.63, 95% CI 1.90-7.46) and long duration of drug use in the past (aOR = 1.06, 95% CI 1.03-1.09) were associated with an increase in the odds of opioid relapse. By contrast, living with many family members (aOR = 0.69, 95% CI 0.55-0.85), having longer treatment time (aOR = 0.80, 95% CI 0.73-0.87), and completely adhering to treatment (aOR = 0.38, 95% CI 0.23-0.64) were protective for opioid relapse. As per the univariate analyses, the odds of opioid relapse declined by 25% for each increase of one close friend or relative (OR = 0.75, 95% CI 0.66-0.86). Regarding social support (range score: 0-100), each additional increase of one score was associated with a 1% decrease in the odds of opioid relapse (OR = 0.99, 95% CI 0.98-0.99). Patient sex, education level, occupation type, patient's monthly income, family's monthly income, the number of previous treatments, daily methadone dose, comorbidity, and received antiretroviral therapy were not associated with opioid relapse among patients (p > 0.05).Conclusions: Residence, the role of family and social support, and treatment adherence should be paid more attention to guarantee and enhance the success of methadone maintenance treatment.","PeriodicalId":12922,"journal":{"name":"Harm Reduction Journal","volume":"20 1","pages":"136"},"PeriodicalIF":4.0000,"publicationDate":"2023-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505306/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Harm Reduction Journal","FirstCategoryId":"90","ListUrlMain":"https://doi.org/10.1186/s12954-023-00872-0","RegionNum":2,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"SUBSTANCE ABUSE","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Opioid relapse, one of the common and severe problems during methadone maintenance treatment, can give rise to poor treatment outcomes. This study measured the opioid relapse rate and its associated factors among methadone maintenance patients in Vietnam.

Methods: Information about the demographic characteristics and social support of 655 patients was collected through direct interviews. Medical records were used to gather data on treatment characteristics. Relapse was determined via urine opioid test results.

Results: The overall relapse rate of patients during treatment was 13.1%. According to the multivariate logistic regression model, living in mountainous areas (adjusted odds ratio (aOR) = 3.63, 95% CI 1.90-7.46) and long duration of drug use in the past (aOR = 1.06, 95% CI 1.03-1.09) were associated with an increase in the odds of opioid relapse. By contrast, living with many family members (aOR = 0.69, 95% CI 0.55-0.85), having longer treatment time (aOR = 0.80, 95% CI 0.73-0.87), and completely adhering to treatment (aOR = 0.38, 95% CI 0.23-0.64) were protective for opioid relapse. As per the univariate analyses, the odds of opioid relapse declined by 25% for each increase of one close friend or relative (OR = 0.75, 95% CI 0.66-0.86). Regarding social support (range score: 0-100), each additional increase of one score was associated with a 1% decrease in the odds of opioid relapse (OR = 0.99, 95% CI 0.98-0.99). Patient sex, education level, occupation type, patient's monthly income, family's monthly income, the number of previous treatments, daily methadone dose, comorbidity, and received antiretroviral therapy were not associated with opioid relapse among patients (p > 0.05).

Conclusions: Residence, the role of family and social support, and treatment adherence should be paid more attention to guarantee and enhance the success of methadone maintenance treatment.

Abstract Image

查看原文本刊更多论文

美沙酮维持期患者阿片类药物复发及其预测因素：一项越南多中心横断面研究。

背景：阿片类药物复发是美沙酮维持治疗中常见且严重的问题之一，可能导致治疗结果不佳。本研究测量了越南美沙酮维持期患者的阿片类药物复发率及其相关因素。方法：通过直接访谈收集655名患者的人口学特征和社会支持信息。医疗记录被用来收集有关治疗特征的数据。通过尿液阿片类药物检测结果确定复发。结果：患者在治疗期间的总复发率为13.1%。根据多变量logistic回归模型，居住在山区（调整比值比（aOR）） = 3.63，95%CI 1.90-7.46）和过去长期用药（aOR = 1.06、95%CI 1.03-1.09）与阿片类药物复发几率的增加相关。相比之下，与许多家庭成员一起生活（aOR = 0.69，95%CI 0.55-0.85），治疗时间较长（aOR = 0.80，95%CI 0.73-0.87），并且完全坚持治疗（aOR = 0.38、95%CI 0.23-0.64）对阿片类药物复发具有保护作用。根据单变量分析，每增加一位亲密朋友或亲戚，阿片类药物复发的几率就会下降25%（or = 0.75，95%CI 0.66-0.86）。关于社会支持（范围得分：0-100），每增加一分，阿片类药物复发的几率就会降低1%（OR = 0.99，95%CI 0.98-0.99）。患者性别、教育水平、职业类型、患者月收入、家庭月收入、既往治疗次数、每日美沙酮剂量、合并症和接受抗逆转录病毒治疗与患者阿片类药物复发无关（p > 结论：应重视居住、家庭和社会支持的作用以及治疗依从性，以保证和提高美沙酮维持治疗的成功率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Harm Reduction Journal Medicine-Public Health, Environmental and Occupational Health

CiteScore

5.90

自引率

9.10%

发文量

126

审稿时长

26 weeks

期刊介绍： Harm Reduction Journal is an Open Access, peer-reviewed, online journal whose focus is on the prevalent patterns of psychoactive drug use, the public policies meant to control them, and the search for effective methods of reducing the adverse medical, public health, and social consequences associated with both drugs and drug policies. We define "harm reduction" as "policies and programs which aim to reduce the health, social, and economic costs of legal and illegal psychoactive drug use without necessarily reducing drug consumption". We are especially interested in studies of the evolving patterns of drug use around the world, their implications for the spread of HIV/AIDS and other blood-borne pathogens.