Anemia is associated with long-term exposure to PM_2.5 and its components: a large population-based study in Southwest China.

IF 3.4 3区医学 Q2 HEMATOLOGY

Therapeutic Advances in Hematology Pub Date : 2023-01-01 DOI:10.1177/20406207231189922

Congyuan He, Linshen Xie, Lingxi Gu, Hongyu Yan, Shiyu Feng, Chunmei Zeng, Wangjiu Danzhen, Xuehui Zhang, Mingming Han, Zhifeng Li, Zhuoma Duoji, Bing Guo, Juying Zhang, Feng Hong, Xing Zhao

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Abstract

Background: Anemia is linked to PM_2.5 (particulate matter with aerodynamic diameters of ⩽2.5 μm) exposure, which can increase the risk of various negative health outcomes. It remains unclear which PM_2.5 components are associated with anemia and the respective contribution of each component to this association.

Objective: This study aimed at investigating the association between PM_2.5 and anemia in the general population and to identify the most critical PM_2.5 toxic components in this association.

Design: Cross-sectional study.

Methods: Our study involved a large cohort of 73,511 individuals aged 30-79 from China's multi-ethnic population. We employed satellite observations and the chemical transport model (GEOS-Chem)to estimate the long-term exposure to PM_2.5 and its components. Anemia was defined, according to WHO guidelines, as Hb levels below 130 g/L for men and below 120 g/L for women. Through logistic regression, we investigated the association between PM_2.5 components and anemia. By utilizing weighted quantile sum (WQS) analysis, we identified key components and gained insights into their combined impact on anemia. Overall, our study sheds light on the relationship between PM_2.5 exposure, its constituents, and the risk of anemia in a large cohort.

Results: PM_2.5 and three components, nitrate (NIT), organic matter (OM), and soil particles (SOIL), were associated with anemia. Per-standard deviation increase in the 3-year average concentrations of PM_2.5 [odds ratio (OR): 1.14, 95% confidence interval (CI): 1.01, 1.28], NIT (1.20, 1.06, 1.35), OM (1.17, 1.04, 1.32), and SOIL (1.22, 1.11, 1.33) were associated with higher odds of anemia. In WQS regression analysis, the WQS index was associated with anemia (OR: 1.29, 95% CI: 1.13, 1.47). SOIL has the highest weight among all PM_2.5 components.

Conclusions: Long-term exposure to PM_2.5 and its constituents is associated with anemia. Moreover, SOIL might be the most critical component of the relationship between PM_2.5 and anemia. Our research increases the evidence of the association between PM_2.5 and anemia in the general population, and targeted emission control measures should be taken into consideration to mitigate the adverse effects of PM_2.5-related anemia.

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贫血与长期暴露于PM2.5及其成分有关:中国西南地区一项基于人群的大型研究

背景:贫血与PM2.5(空气动力学直径为≥2.5 μm的颗粒物)暴露有关，可增加各种负面健康结果的风险。目前尚不清楚PM2.5的哪些成分与贫血有关，以及每种成分对这种联系的各自贡献。目的:本研究旨在调查PM2.5与普通人群贫血之间的关系，并确定在这种关系中最关键的PM2.5毒性成分。设计:横断面研究。方法:我们的研究涉及73,511名年龄在30-79岁之间的中国多民族人群。我们采用卫星观测和化学输运模型(GEOS-Chem)来估计PM2.5及其组分的长期暴露。根据世卫组织指南，贫血的定义是男性血红蛋白水平低于130克/升，女性血红蛋白水平低于120克/升。通过logistic回归，我们研究了PM2.5成分与贫血之间的关系。通过加权分位数和(WQS)分析，我们确定了关键成分，并深入了解了它们对贫血的综合影响。总的来说，我们的研究揭示了PM2.5暴露及其成分与大量队列中贫血风险之间的关系。结果:PM2.5及硝酸盐(NIT)、有机质(OM)、土壤颗粒(soil)三组分与贫血有关。PM2.5 3年平均浓度的每标准差增加[比值比(OR): 1.14, 95%可信区间(CI): 1.01, 1.28]、NIT(1.20, 1.06, 1.35)、OM(1.17, 1.04, 1.32)和SOIL(1.22, 1.11, 1.33)与贫血的高发生率相关。在WQS回归分析中，WQS指数与贫血相关(OR: 1.29, 95% CI: 1.13, 1.47)。土壤在PM2.5各组分中权重最高。结论:长期暴露于PM2.5及其成分与贫血有关。此外，土壤可能是PM2.5与贫血关系中最关键的组成部分。我们的研究增加了PM2.5与普通人群贫血之间关联的证据，应该考虑有针对性的排放控制措施，以减轻PM2.5相关性贫血的不良影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Therapeutic Advances in Hematology HEMATOLOGY-

CiteScore

4.30

自引率

0.00%

发文量

审稿时长

7 weeks

期刊介绍： Therapeutic Advances in Hematology delivers the highest quality peer-reviewed articles, reviews, and scholarly comment on pioneering efforts and innovative studies across all areas of hematology. The journal has a strong clinical and pharmacological focus and is aimed at clinicians and researchers in hematology, providing a forum in print and online for publishing the highest quality articles in this area.