Because I'm happy - positive affect and its predictive value for future disease activity in patients with inflammatory bowel diseases: a retrospective cohort study.

IF 4.2 3区 医学
Therapeutic Advances in Gastroenterology Pub Date : 2023-06-17 eCollection Date: 2023-01-01 DOI:10.1177/17562848231179335
Brian M Lang, Martina Ledergerber, Sebastian Bruno Ulrich Jordi, Niklas Krupka, Luc Biedermann, Philipp Schreiner, Pascal Juillerat, Jacqueline Wyss, Stephan R Vavricka, Jonas Zeitz, Roland von Känel, Gerhard Rogler, Niko Beerenwinkel, Benjamin Misselwitz
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引用次数: 0

Abstract

Background: While the detrimental impact of negative emotions on the clinical course of inflammatory bowel disease (IBD) and quality of life has been extensively investigated, evidence for a potential impact of positive emotions is scarce.

Objectives: We aim to analyse contributing factors of positive affect and their predictive value for disease course in IBD patients.

Design: In this retrospective cohort study, epidemiological, psychosocial and IBD disease characteristics of Swiss IBD cohort study patients were analysed longitudinally.

Methods: Epidemiological, psychosocial and disease characteristics were extracted from the database of the Swiss IBD cohort study. Participants' positive emotions were assessed cross-sectionally with the seven-item Marburg questionnaire (range 1-6) addressing positive affect in different aspects of daily life. Predictors of positive emotions were identified by linear regression. The quantitative longitudinal impact of positive emotions on the further disease course was analysed using a multivariable Cox proportional hazards model.

Results: Among 702 IBD patients, those reporting more positive emotions were found to have significantly less intense medical treatment, less pain and fewer depressive symptoms (p < 0.05). A higher percentage of variability in positive emotions was explained by pain (36%) and depressive symptoms (13%) than by epidemiological characteristics (0.3%), or characteristics of IBD and its treatment (2.4%). Patients with higher levels of positive emotions (score > 3.5) experienced longer flare-free survival, also after adjusting for confounders (adjusted hazard ratio: 0.39, p < 0.05).

Conclusions: The absence of pain and depressive symptoms were the strongest drivers for high positive affect. Higher scores of positive affect were associated with longer disease-free survival in IBD patients.

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因为我快乐--炎症性肠病患者的积极情绪及其对未来疾病活动的预测价值:一项回顾性队列研究。
背景:负面情绪对炎症性肠病(IBD)的临床病程和生活质量的不利影响已得到广泛研究:负面情绪对炎症性肠病(IBD)的临床病程和生活质量的不利影响已得到广泛研究,但有关积极情绪潜在影响的证据却很少:我们旨在分析积极情绪的诱因及其对 IBD 患者病程的预测价值:在这项回顾性队列研究中,我们对瑞士 IBD 队列研究患者的流行病学、社会心理和 IBD 疾病特征进行了纵向分析:方法:从瑞士 IBD 队列研究数据库中提取流行病学、社会心理和疾病特征。参与者的积极情绪通过七项马尔堡问卷(范围 1-6)进行横向评估,该问卷涉及日常生活中不同方面的积极情绪。通过线性回归确定了积极情绪的预测因素。采用多变量考克斯比例危险模型分析了积极情绪对进一步病程的定量纵向影响:结果:在 702 名 IBD 患者中,报告积极情绪较多的患者接受的治疗强度明显较小、疼痛较轻、抑郁症状较少 (p 3.5),而且在调整了混杂因素后,他们的无发作生存期也更长(调整后危险比:0.39,p 结论:在 702 名 IBD 患者中,报告积极情绪较多的患者接受的治疗强度明显较小、疼痛较轻、抑郁症状较少 (p 3.5),而且他们的无发作生存期也更长:无疼痛和抑郁症状是高积极情绪的最强驱动力。积极情绪得分越高,IBD 患者的无病生存期越长。
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来源期刊
Therapeutic Advances in Gastroenterology
Therapeutic Advances in Gastroenterology Medicine-Gastroenterology
自引率
2.40%
发文量
103
期刊介绍: Therapeutic Advances in Gastroenterology is an open access journal which delivers the highest quality peer-reviewed original research articles, reviews, and scholarly comment on pioneering efforts and innovative studies in the medical treatment of gastrointestinal and hepatic disorders. The journal has a strong clinical and pharmacological focus and is aimed at an international audience of clinicians and researchers in gastroenterology and related disciplines, providing an online forum for rapid dissemination of recent research and perspectives in this area. The editors welcome original research articles across all areas of gastroenterology and hepatology. The journal publishes original research articles and review articles primarily. Original research manuscripts may include laboratory, animal or human/clinical studies – all phases. Letters to the Editor and Case Reports will also be considered.
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