The Role of Gynostemma pentaphyllum in Regulating Hyperlipidemia.

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL

ACS Applied Energy Materials Pub Date : 2023-01-01 DOI:10.1142/S0192415X23500441

Ying Li, Qiong Ouyang, Xu Li, Raphael N Alolgal, Yuanming Fan, Yangyang Sun, Hang Gong, Pingxi Xiao, Gaoxiang Ma

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Abstract

Developing effective and safe lipid-lowering drugs is highly urgent. This study aims to investigate the effectiveness and underlying mechanisms of Gynostemma pentaphyllum (GP) in the treatment of hyperlipidemia. First, a meta-analysis was performed to determine the lipid-lowering effects of GP. Thereafter, hyperlipidemia was induced in mice using a high-fat diet (HFD) and was subsequently treated with Gynostemma pentaphyllum extract (GPE) by daily gavage for 12 weeks. The body weight, tissue weight, blood lipid level, and liver lipid level were determined. Additionally, mouse serum samples were subjected to metabolomic profiling and feces were collected at different time points for metagenomic analysis via 16S rDNA sequencing. A total of 15 out of 1520 studies were retrieved from six databases. The pooled results of the meta-analysis showed that GP effectively reduced triglyceride levels and increased high-density lipoprotein cholesterol (both [Formula: see text]). Animal experiments revealed that GPE administration significantly reduced body weight, ameliorated high blood lipid levels, limited lipid deposition, and improved insulin resistance. Furthermore, GPE treatment markedly changed the intestinal microbiota structure and constitution of tryptophan metabolites. In conclusion, our results confirm the lipid-lowering effect of GP, which may be partly attributable to regulation of the intestinal microbiota and tryptophan metabolism.

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绞股蓝对高脂血症的调节作用。

开发有效、安全的降脂药物迫在眉睫。本研究旨在探讨绞股蓝(Gynostemma pentaphyllum, GP)治疗高脂血症的疗效及其机制。首先，进行荟萃分析以确定GP的降脂作用。随后，采用高脂饮食(HFD)诱导小鼠高脂血症，随后每天灌胃绞股蓝提取物(GPE)，持续12周。测定大鼠体重、组织重量、血脂水平、肝脂水平。此外，对小鼠血清样本进行代谢组学分析，并在不同时间点收集粪便，通过16S rDNA测序进行宏基因组分析。从6个数据库中检索了1520项研究中的15项。荟萃分析的综合结果显示，GP有效地降低了甘油三酯水平，增加了高密度脂蛋白胆固醇(两者都是[公式:见正文])。动物实验显示，GPE可显著降低体重，改善高血脂水平，限制脂质沉积，改善胰岛素抵抗。此外，GPE处理显著改变了肠道菌群结构和色氨酸代谢物组成。总之，我们的研究结果证实了GP的降脂作用，这可能部分归因于肠道微生物群和色氨酸代谢的调节。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.