{"title":"Ginsenosides are Promising Medicine for Tumor and Inflammation: A Review.","authors":"Jiawei Li, Fangfang Li, Dan Jin","doi":"10.1142/S0192415X23500416","DOIUrl":null,"url":null,"abstract":"<p><p>Ginseng is a valuable medicinal plant in Asian countries with thousands of years of history. Ginsenosides, one of the active components of ginseng, are considered to be of potential value in the treatment of various diseases. The antitumor effects of ginsenosides, such as Rg3, Rh2, Rg5, and CK, are well known, and their potential mechanisms are thought to be related to inducing apoptosis, enhancing the immune response, reversing drug resistance to chemotherapy, and regulating signaling pathways, such as MAPK, PI3K/Akt/mTOR, Wnt/[Formula: see text]-catenin, NF-[Formula: see text]B, ASK-1/JNK, AMPK, and EGFR/Akt/SOX2. On the other hand, ginsenosides also have anti-inflammatory effects, including reducing the release of inflammatory factors, regulating the balance of immune cells, regulating the diversity of intestinal flora, and activating MAPK, NF-[Formula: see text]B, and NLRP3 inflammasomes. These data suggest that ginsenosides may provide new insights as promising drugs for the treatment of malignant tumors and inflammatory diseases.</p>","PeriodicalId":50814,"journal":{"name":"American Journal of Chinese Medicine","volume":"51 4","pages":"883-908"},"PeriodicalIF":4.8000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Chinese Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1142/S0192415X23500416","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
Ginseng is a valuable medicinal plant in Asian countries with thousands of years of history. Ginsenosides, one of the active components of ginseng, are considered to be of potential value in the treatment of various diseases. The antitumor effects of ginsenosides, such as Rg3, Rh2, Rg5, and CK, are well known, and their potential mechanisms are thought to be related to inducing apoptosis, enhancing the immune response, reversing drug resistance to chemotherapy, and regulating signaling pathways, such as MAPK, PI3K/Akt/mTOR, Wnt/[Formula: see text]-catenin, NF-[Formula: see text]B, ASK-1/JNK, AMPK, and EGFR/Akt/SOX2. On the other hand, ginsenosides also have anti-inflammatory effects, including reducing the release of inflammatory factors, regulating the balance of immune cells, regulating the diversity of intestinal flora, and activating MAPK, NF-[Formula: see text]B, and NLRP3 inflammasomes. These data suggest that ginsenosides may provide new insights as promising drugs for the treatment of malignant tumors and inflammatory diseases.
期刊介绍：
The American Journal of Chinese Medicine, which is defined in its broadest sense possible, publishes original articles and essays relating to traditional or ethnomedicine of all cultures. Areas of particular interest include:
Basic scientific and clinical research in indigenous medical techniques, therapeutic procedures, medicinal plants, and traditional medical theories and concepts;
Multidisciplinary study of medical practice and health care, especially from historical, cultural, public health, and socioeconomic perspectives;
International policy implications of comparative studies of medicine in all cultures, including such issues as health in developing countries, affordability and transferability of health-care techniques and concepts;
Translating scholarly ancient texts or modern publications on ethnomedicine.
The American Journal of Chinese Medicine will consider for publication a broad range of scholarly contributions, including original scientific research papers, review articles, editorial comments, social policy statements, brief news items, bibliographies, research guides, letters to the editors, book reviews, and selected reprints.
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