A TOX-ic axis of epigenetic stem cell maintenance and chemoresistance in colon cancer.

IF 7.8 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

PLoS Biology Pub Date : 2023-09-15 eCollection Date: 2023-09-01 DOI:10.1371/journal.pbio.3002295

Christopher G Hubert, Shaun R Stauffer, Justin D Lathia

引用次数: 0

Abstract

Cancer stem cells drive tumor growth and survival via self-renewal and therapeutic resistance, but the upstream mechanisms are not well defined. In this issue of PLOS Biology, a study in colon cancer reveals a new signalling network that links epigenetic regulation to these phenotypes.

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癌症表观遗传干细胞维持和化疗耐药性的TOX-ic轴。

癌症干细胞通过自我更新和治疗耐药性驱动肿瘤生长和存活，但其上游机制尚不明确。在本期《公共科学图书馆生物学》杂志上，一项针对癌症的研究揭示了一种新的信号网络，它将表观遗传调控与这些表型联系起来。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

PLoS Biology 生物-生化与分子生物学

CiteScore

14.40

自引率

2.00%

发文量

359

审稿时长

3 months

期刊介绍： PLOS Biology is an open-access, peer-reviewed general biology journal published by PLOS, a nonprofit organization of scientists and physicians dedicated to making the world's scientific and medical literature freely accessible. The journal publishes new articles online weekly, with issues compiled and published monthly. ISSN Numbers: eISSN: 1545-7885 ISSN: 1544-9173