Association between serum sodium and 28-day mortality in sepsis patients: A secondary data analysis from three large critical illness cohorts.

IF 1.5 4区医学 Q3 HEMATOLOGY

Therapeutic Apheresis and Dialysis Pub Date : 2024-02-01 Epub Date: 2023-09-13 DOI:10.1111/1744-9987.14066

Wei Li, Shuwen Li, Jia Yuan, Xianjun Chen, Qimin Chen, Chuan Xiao, Qing Li, Lu Li, Ying Liu, Juan He, Lu Chen, Feng Shen

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引用次数: 0

Abstract

Objective: The present study was designed to explore the association between serum sodium and mortality in patients with sepsis by using a large sample, multicenter MIMIC-IV database.

Methods: We extracted the data of 34 925 sepsis patients from the retrospective cohort mimicIV database. After adjusting the confounders, we explored the independent effects of serum sodium on 28-day mortality.

Results: A nonlinear relationship existed between serum sodium and 28-day mortality, of which a negative association was found between serum sodium and 28-day mortality (odds ratio: 0.95, 95% CI: 0.94, 0.96, p = 0.0001) when serum sodium was in 102 mmol/L to 138 mmol/L, but a positive correlation appeared when sodium climbed to the range of 140-179 mmol/L (odds ratio: 1.04, 95% CI: 1.03-1.06, p = 0.0001).

Conclusions: Both lower and higher serum sodium levels are associated with an increased risk of death in sepsis patients.

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败血症患者血清钠与 28 天死亡率之间的关系：来自三个大型危重病队列的二次数据分析。

目的：本研究旨在通过大样本、多中心 MIMIC-IV 数据库探讨败血症患者血清钠与死亡率之间的关系：本研究旨在利用大样本、多中心 MIMIC-IV 数据库探讨脓毒症患者血清钠与死亡率之间的关系：我们从回顾性队列 mimic-IV 数据库中提取了 34 925 名败血症患者的数据。调整混杂因素后，我们探讨了血清钠对 28 天死亡率的独立影响：血清钠与 28 天死亡率之间存在非线性关系，其中当血清钠在 102 mmol/L 至 138 mmol/L 之间时，血清钠与 28 天死亡率之间呈负相关（几率比：0.95，95% CI：0.94，0.96，P = 0.0001），但当血清钠攀升至 140-179 mmol/L 之间时，两者之间呈正相关（几率比：1.04，95% CI：1.03-1.06，P = 0.0001）：结论：较低和较高的血清钠水平都与脓毒症患者死亡风险的增加有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Therapeutic Apheresis and Dialysis 医学-泌尿学与肾脏学

CiteScore

3.00

自引率

10.50%

发文量

166

审稿时长

6-12 weeks

期刊介绍： Therapeutic Apheresis and Dialysis is the official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis and the Japanese Society for Dialysis Therapy. The Journal publishes original articles, editorial comments, review articles, case reports, meeting abstracts and Communications information on apheresis and dialysis technologies and treatments.