Cell-free DNA in large B-cell lymphoma: MRD and beyond

IF 5 3区医学 Q1 HEMATOLOGY

Seminars in hematology Pub Date : 2023-07-01 DOI:10.1053/j.seminhematol.2023.06.004

Brian J. Sworder , David M. Kurtz

引用次数: 0

Abstract

Large B-cell lymphomas (LBCLs) are a strikingly diverse set of diseases, including clinical, biological, and molecular heterogeneity. Despite a wealth of information resolving this heterogeneity in the research setting, applying molecular features routinely in the clinic remains challenging. The advent of circulating tumor DNA (ctDNA) liquid biopsies promises to unlock additional molecular information in the clinic, including mutational genotyping, molecular classification, and minimal residual disease detection. Here, we examine the technologies, applications, and studies exploring the utility of ctDNA in LBCLs.

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大B细胞淋巴瘤的无细胞DNA：MRD及以后的研究。

大B细胞淋巴瘤（LBCL）是一组极其多样化的疾病，包括临床、生物学和分子异质性。尽管在研究环境中有丰富的信息解决了这种异质性，但在临床中常规应用分子特征仍然具有挑战性。循环肿瘤DNA（ctDNA）液体活检的出现有望在临床上解锁更多的分子信息，包括突变基因分型、分子分类和最小残留疾病检测。在这里，我们研究了ctDNA在LBCL中的应用的技术、应用和研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in hematology 医学-血液学

CiteScore

6.20

自引率

2.80%

发文量

审稿时长

35 days

期刊介绍： Seminars in Hematology aims to present subjects of current importance in clinical hematology, including related areas of oncology, hematopathology, and blood banking. The journal''s unique issue structure allows for a multi-faceted overview of a single topic via a curated selection of review articles, while also offering a variety of articles that present dynamic and front-line material immediately influencing the field. Seminars in Hematology is devoted to making the important and current work accessible, comprehensible, and valuable to the practicing physician, young investigator, clinical practitioners, and internists/paediatricians with strong interests in blood diseases. Seminars in Hematology publishes original research, reviews, short communications and mini- reviews.