Comparing high-flow nasal oxygen therapy and normobaric oxygen therapy on the treatment of carbon monoxide poisoning.

IF 1.3 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Medizinische Klinik-Intensivmedizin Und Notfallmedizin Pub Date : 2024-04-01 Epub Date: 2023-08-02 DOI:10.1007/s00063-023-01044-5

Sedat Akkan, Ömür Uyanik

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引用次数: 0

Abstract

Aim: We aimed to investigate whether there is a difference in the rate of decrease in carboxyhemoglobin (COHB) values between high-flow nasal oxygen (HFNO) and normobaric oxygen (NBO) therapy.

Material and method: This retrospective observational study included patients with carbon monoxide poisoning who were treated with HFNO or NBO (control group). All patients were started on NBO therapy with a non-rebreather face mask at a rate of 15 L/min. In the NBO group, NBO treatment was continued until the COHB value fell below 10%. In the HFNO group, as soon as the preparation of the HFNO device was completed, NBO treatment was terminated and HFNO treatment was started and continued until the COHB value fell below 10%. The primary outcome of the study was the difference between HFNO and NBO in terms of COHB half-life rates.

Results: A total of 81 patients were included in the study, 44 in the HFNO group and 37 in the NBO group. The median of COHB t_1/2 values between HFNO and the NBO treatment groups were 47.3 (IQR: 25-75%: 31.5-65.4) and 46 (IQR: 25-75%: 32.3-56.2), respectively, but this difference was not statistically significant (p = 0.81).

Conclusion: The results of this study suggest that HFNO treatment does not have a significant advantage over NBO treatment in the carbon monoxide elimination rate within the first 60 min of treatment.

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比较高流量鼻氧疗法和常压氧疗法对一氧化碳中毒的治疗效果。

目的：我们旨在研究高流量鼻氧（HFNO）和常压氧（NBO）疗法在碳氧血红蛋白（COHB）值下降率方面是否存在差异：这项回顾性观察研究包括接受高流量鼻氧疗法或常压氧疗法治疗的一氧化碳中毒患者（对照组）。所有患者均开始使用非呼吸面罩进行 NBO 治疗，呼吸频率为 15 升/分钟。在 NBO 组，NBO 治疗一直持续到 COHB 值低于 10%。在 HFNO 组，一旦完成 HFNO 装置的准备工作，即终止 NBO 治疗，开始 HFNO 治疗，并持续到 COHB 值降至 10%以下。研究的主要结果是 HFNO 和 NBO 在 COHB 半衰期率方面的差异：研究共纳入了 81 名患者，其中高频硝化甘油组 44 人，低频硝化甘油组 37 人。HFNO 组和 NBO 治疗组 COHB t1/2 值的中位数分别为 47.3（IQR：25-75%：31.5-65.4）和 46（IQR：25-75%：32.3-56.2），但差异无统计学意义（P = 0.81）：本研究结果表明，与 NBO 治疗相比，高频硝化氧治疗在治疗后 60 分钟内的一氧化碳排出率并无明显优势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medizinische Klinik-Intensivmedizin Und Notfallmedizin MEDICINE, GENERAL & INTERNAL-

CiteScore

2.60

自引率

9.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Medizinische Klinik – Intensivmedizin und Notfallmedizin is an internationally respected interdisciplinary journal. It is intended for physicians, nurses, respiratory and physical therapists active in intensive care and accident/emergency units, but also for internists, anesthesiologists, surgeons, neurologists, and pediatricians with special interest in intensive care medicine. Comprehensive reviews describe the most recent advances in the field of internal medicine with special focus on intensive care problems. Freely submitted original articles present important studies in this discipline and promote scientific exchange, while articles in the category Photo essay feature interesting cases and aim at optimizing diagnostic and therapeutic strategies. In the rubric journal club well-respected experts comment on outstanding international publications. Review articles under the rubric "Continuing Medical Education" present verified results of scientific research and their integration into daily practice. The rubrics "Nursing practice" and "Physical therapy" round out the information.