Human milk EV-miRNAs: a novel biomarker for air pollution exposure during pregnancy.

Environmental research, health : ERH Pub Date : 2023-09-01 Epub Date: 2023-06-30 DOI:10.1088/2752-5309/ace075
Elizabeth A Holzhausen, Allison Kupsco, Bridget N Chalifour, William B Patterson, Kelsey A Schmidt, Pari Mokhtari, Fredrick Lurmann, Andrea A Baccarelli, Michael I Goran, Tanya L Alderete
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Abstract

Exposure to ambient and near-roadway air pollution during pregnancy has been linked with several adverse health outcomes for pregnant women and their babies. Emerging research indicates that microRNA (miRNA) expression can be altered by exposure to air pollutants in a variety of tissues. Additionally, miRNAs from breast tissue and circulating miRNAs have previously been proposed as a biomarker for breast cancer diagnosis and prognosis. Therefore, this study sought to evaluate the associations between pregnancy exposures to ambient (PM10, PM2.5, NO2, O3) and near-roadway air pollution (total NOx, freeway NOx, non-freeway NOx) with breast milk extracellular vesicle miRNA (EV-miRNA), measured at 1-month postpartum, in a cohort of 108 Latina women living in Southern California. We found that PM10 exposure during pregnancy was positively associated with hsa-miR-200c-3p, hsa-miR-200b-3p, and hsa-let-7c-5p, and was negatively associated with hsa-miR-378d. We also found that pregnancy PM2.5 exposure was positively associated with hsa-miR-200c-3p and hsa-miR-200b-3p. First and second trimester exposure to PM10 and PM2.5 was associated with several EV-miRNAs with putative messenger RNA targets related to cancer. This study provides preliminary evidence that air pollution exposure during pregnancy is associated with human milk EV-miRNA expression.

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母乳EV miRNAs:妊娠期空气污染暴露的新生物标志物。
怀孕期间暴露于环境和道路附近的空气污染与孕妇及其婴儿的几种不良健康后果有关。新兴的研究表明,暴露于各种组织中的空气污染物可以改变微小RNA(miRNA)的表达。此外,来自乳腺组织和循环miRNA的miRNA先前已被提议作为乳腺癌症诊断和预后的生物标志物。因此,本研究试图评估妊娠期暴露于环境(PM10、PM2.5、NO2、O3)和近道路空气污染(总氮氧化物、高速公路氮氧化物、非高速公路氮氧化物)与母乳细胞外小泡miRNA(EV-miRNA)之间的关系,该研究在产后1个月对居住在南加州的108名拉丁裔女性进行了测量。我们发现,妊娠期PM10暴露与hsa-miR-200c-3p、hsa-miR-200 b-3p和hsa-let-7c-5p呈正相关,与hsa-iR-378d呈负相关。我们还发现,妊娠期PM2.5暴露与hsa-miR-200c-3p和hsa-miR-200 b-3p呈正相关。妊娠早期和中期暴露于PM10和PM2.5与几种EV-mRNA相关,这些EV-mRNA具有与癌症相关的假定信使RNA靶点。这项研究提供了初步证据,证明怀孕期间暴露于空气污染与母乳EV miRNA表达有关。
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