The added value of CA125, HE4, and CA72-4 as markers for ovarian endometriosis diagnosis.

IF 1.2 4区医学 Q4 DEVELOPMENTAL BIOLOGY

Romanian Journal of Morphology and Embryology Pub Date : 2023-04-01 DOI:10.47162/RJME.64.2.05

Romeo Micu, Adriana Maria Ioana Gaia-Oltean, Livia Budişan, Cornelia Braicu, Alexandru Irimie, Ioana Berindan-Neagoe

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引用次数: 0

Abstract

Objective: This study aimed to evaluate the prognostic value as diagnosis makers of cancer antigen (CA)125, human epididymis 4 (HE4), and CA72-4 serum levels in ovarian endometriosis (OvEndo).

Patients, materials and methods: The serum levels of CA125, HE4, and CA72-4 were measured using enzyme-linked immunosorbent assay (ELISA) technique for a group of 29 cases of OvEndo and a control (CTR) group of 26 cases.

Results: Results were compared between groups and statistical correlation was analyzed between the three biomarkers. (i) For CA125, we found a statistically significant difference in-between the mean serum levels of the two groups: 9.02 U∕mL in the OvEndo group versus 7.1 U∕mL in the CTR group (p=0.0158). (ii) A similar situation was found for CA72-4 levels in OvEndo group, where the mean serum level was 6.1 U∕mL compared to 3.5 U∕mL in the CTR group, showing a significant difference (p=0.0185). (iii) The mean serum level of HE4 in the OvEndo group was 7.6 ng∕mL versus 7.8 ng∕mL in the CTR group, and we found it highly significant (p=0.0001). HE4 levels were highly correlated with CA72-4 levels (p<0.0001), while CA125 levels were not correlated with HE4 and CA72-4.

Conclusions: Measurements of CA125 can be used in the diagnosis of OvEndo mainly in association with HE4 serum levels, which are lower in endometriosis patients. CA72-4 levels are highly correlated with HE4 levels in patients with OvEndo, while no correlation with the other two markers was found. This correlation needs further investigation to establish if it may be used as a possible diagnostic tool in clinical practice.

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CA125、HE4和CA72-4作为卵巢子宫内膜异位症诊断标志物的附加值。

目的：评价血清癌症抗原（CA）125、人附睾4（HE4）和CA72-4水平对卵巢子宫内膜异位症（OvEndo）的诊断价值，应用酶联免疫吸附试验（ELISA）技术对29例OvEndo和26例对照组（CTR）的CA72-4进行了测定。结果：比较各组之间的结果，并分析三种生物标志物之间的统计学相关性。（i）对于CA125，我们发现两组的平均血清水平之间存在统计学显著差异：OvEndo组为9.02 U／mL，CTR组为7.1 U／mL（p=0.0158），（iii）OvEndo组的平均血清HE4水平为7.6ng／mL，CTR组为7.8ng／mL，HE4水平与CA72-4水平高度相关（结论：CA125的测定可用于诊断OvEndo，主要与子宫内膜异位症患者血清中HE4水平有关，而HE4水平较低。CA72-4水平与OvEndo患者的HE4水平高度相关，而与其他两种标志物没有相关性。这种相关性需要进一步研究，以确定它是否可以作为一种可能的诊断c工具在临床实践中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Romanian Journal of Morphology and Embryology DEVELOPMENTAL BIOLOGY-

CiteScore

1.70

自引率

20.00%

发文量

221

审稿时长

3-8 weeks

期刊介绍： Romanian Journal of Morphology and Embryology (Rom J Morphol Embryol) publishes studies on all aspects of normal morphology and human comparative and experimental pathology. The Journal accepts only researches that utilize modern investigation methods (studies of anatomy, pathology, cytopathology, immunohistochemistry, histochemistry, immunology, morphometry, molecular and cellular biology, electronic microscopy, etc.).