Natural antioxidants mitigate heavy metal induced reproductive toxicity: prospective mechanisms and biomarkers.

IF 7.3 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY
Yueyao Fan, Xinwei Jiang, Yuhang Xiao, Haiwei Li, Jiali Chen, Weibin Bai
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引用次数: 0

Abstract

Heavy metals are harmful environmental pollutants that have attracted widespread attention, attributed to their health hazards to humans and animals. Due to the non-degradable property of heavy metals, organisms are inevitably exposed to heavy metals such as arsenic (As), cadmium (Cd), lead (Pb), and mercury (Hg). Several studies revealed that heavy metals can cause reproductive damage by the excessive production of reactive oxygen species (ROS), which exacerbates oxidative stress, inflammation, and endocrine disruption. Natural antioxidants, mainly polyphenols, carotenoids, and vitamins, have been shown to mitigate heavy metal-induced reproductive toxicity potentially. In this review, accumulated evidences on the influences of four non-essential heavy metals As, Cd, Pb, and Hg on both males and females reproductive system were established. The purpose of this review is to explore the potential mechanisms of the effects of heavy metals on reproductive function and point out the potential biomarkers of natural antioxidants interventions toward heavy metal-induced reproductive toxicity. Notably, increasing evidence proven that the regulations of hypothalamic-pituitary-gonadal axis, Nrf2, MAPK, or NF-κB pathways are the important mechanisms for the amelioration of heavy metal induced reproductive toxicity by natural antioxidants. It also provided a promising guidance for prevention and management of heavy metal-induced reproductive toxicity.

天然抗氧化剂减轻重金属引起的生殖毒性:前瞻性机制和生物标志物。
重金属是一种有害的环境污染物,因其对人类和动物健康的危害而受到广泛关注。由于重金属具有不可降解的特性,生物体不可避免地会接触到砷(As)、镉(Cd)、铅(Pb)和汞(Hg)等重金属。多项研究表明,重金属会产生过多的活性氧(ROS),加剧氧化应激、炎症和内分泌紊乱,从而对生殖系统造成损害。天然抗氧化剂,主要是多酚、类胡萝卜素和维生素,已被证明可以减轻重金属引起的潜在生殖毒性。在这篇综述中,已积累了有关四种非必需重金属砷、镉、铅和汞对男性和女性生殖系统影响的证据。本综述旨在探讨重金属对生殖功能影响的潜在机制,并指出天然抗氧化剂干预重金属引起的生殖毒性的潜在生物标志物。值得注意的是,越来越多的证据证明,下丘脑-垂体-性腺轴、Nrf2、MAPK 或 NF-κB 通路的调节是天然抗氧化剂改善重金属诱导的生殖毒性的重要机制。这也为重金属诱导的生殖毒性的预防和管理提供了很好的指导。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
22.60
自引率
4.90%
发文量
600
审稿时长
7.5 months
期刊介绍: Critical Reviews in Food Science and Nutrition serves as an authoritative outlet for critical perspectives on contemporary technology, food science, and human nutrition. With a specific focus on issues of national significance, particularly for food scientists, nutritionists, and health professionals, the journal delves into nutrition, functional foods, food safety, and food science and technology. Research areas span diverse topics such as diet and disease, antioxidants, allergenicity, microbiological concerns, flavor chemistry, nutrient roles and bioavailability, pesticides, toxic chemicals and regulation, risk assessment, food safety, and emerging food products, ingredients, and technologies.
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