KRAB zinc finger protein ZNF676 controls the transcriptional influence of LTR12-related endogenous retrovirus sequences.

IF 4.7 2区生物学 Q1 GENETICS & HEREDITY

Mobile DNA Pub Date : 2022-01-18 DOI:10.1186/s13100-021-00260-0

Alexandra Iouranova, Delphine Grun, Tamara Rossy, Julien Duc, Alexandre Coudray, Michael Imbeault, Jonas de Tribolet-Hardy, Priscilla Turelli, Alexandre Persat, Didier Trono

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Abstract

Background: Transposable element-embedded regulatory sequences (TEeRS) and their KRAB-containing zinc finger protein (KZFP) controllers are increasingly recognized as modulators of gene expression. We aim to characterize the contribution of this system to gene regulation in early human development and germ cells.

Results: Here, after studying genes driven by the long terminal repeat (LTR) of endogenous retroviruses, we identify the ape-restricted ZNF676 as the sequence-specific repressor of a subset of contemporary LTR12 integrants responsible for a large fraction of transpochimeric gene transcripts (TcGTs) generated during human early embryogenesis. We go on to reveal that the binding of this KZFP correlates with the epigenetic marking of these TEeRS in the germline, and is crucial to the control of genes involved in ciliogenesis/flagellogenesis, a biological process that dates back to the last common ancestor of eukaryotes.

Conclusion: These results illustrate how KZFPs and their TE targets contribute to the evolutionary turnover of transcription networks and participate in the transgenerational inheritance of epigenetic traits.

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KRAB 锌指蛋白 ZNF676 控制着 LTR12 相关内源性逆转录病毒序列的转录影响。

背景：可转座元件嵌入调控序列（TEeRS）及其含KRAB锌指蛋白（KZFP）的调控因子越来越被认为是基因表达的调控因子。我们的目的是描述这一系统对人类早期发育和生殖细胞中基因调控的贡献：结果：在对内源性逆转录病毒长末端重复序列（LTR）驱动的基因进行研究后，我们发现猿限制性 ZNF676 是当代 LTR12 整合子集的序列特异性抑制因子，它负责人类早期胚胎发育过程中产生的大部分跨单体基因转录本（TcGTs）。我们接着揭示了这种 KZFP 的结合与这些 TEeRS 在生殖系中的表观遗传标记相关，并且对控制参与纤毛生成/鞭毛生成的基因至关重要，这一生物过程可追溯到真核生物的最后一个共同祖先：这些结果说明了 KZFPs 及其 TE 靶标是如何促进转录网络的进化更替并参与表观遗传特征的跨代遗传的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mobile DNA GENETICS & HEREDITY-

CiteScore

8.20

自引率

6.10%

发文量

审稿时长

11 weeks

期刊介绍： Mobile DNA is an online, peer-reviewed, open access journal that publishes articles providing novel insights into DNA rearrangements in all organisms, ranging from transposition and other types of recombination mechanisms to patterns and processes of mobile element and host genome evolution. In addition, the journal will consider articles on the utility of mobile genetic elements in biotechnological methods and protocols.