Serum brain-derived neurotrophic factor levels as a predictor for Alzheimer disease progression.

IF 1.9 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Meng-Ju Tsai, Yung-Shuan Lin, Chun-Yu Chen, Wei-Ju Lee, Jong-Ling Fuh
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引用次数: 0

Abstract

Background: Brain-derived neurotrophic factor (BDNF) has been implicated in the pathophysiology of Alzheimer's disease (AD), and decreased peripheral levels of this protein are associated with an increased risk of developing the disease. This study focuses on whether serum BDNF levels could be used as a predictor of AD progression.

Methods: In this longitudinal observational study, we recruited cognition normal participants (N = 98) and AD (N = 442) from the Clinic at the Taipei Veterans General Hospital. We conducted a mini-mental status exam, a 12-item memory test, a categorical verbal fluency test, and a modified 15-item Boston naming test. A Serum BDNF level and apolipoprotein E ( APOE ) allele status were measured. The AD patients were followed prospectively. Based on the difference of MMSE scores, these patients were divided into fast decliners (decline ≥ 3/y) and slow decliners (MMSE decline < 3/y). Logistic regression was conducted to examine the impact of serum BDNF levels and other factor on the likelihood of AD patients being slow decliners. Pearson's correlation was used to estimate the relationship between serum BDNF levels and the score of neuropsychological tests.

Results: In a logistic regression model containing serum BDNF levels, age, sex, APOE4 carrier status, education levels, and baseline MMSE score, higher serum BDNF levels were associated with a slower rate of cognitive decline in the AD group. Serum BDNF levels positively correlated with the results of multiple neuropsychological tests.

Conclusion: BDNF is a protective factor against AD progression and likely plays a role in establishing a link between AD pathology and clinical manifestations.

血清脑源性神经营养因子水平作为阿尔茨海默病进展的预测因子。
背景:脑源性神经营养因子(BDNF)与阿尔茨海默病(AD)的病理生理学有关,该蛋白外周水平的降低与发病风险的增加有关。这项研究的重点是血清BDNF水平是否可以作为AD进展的预测指标。方法:在这项纵向观察研究中,我们从台北荣总医院的诊所招募了认知正常的参与者(N=98)和AD(N=442)。我们进行了一项小型心理状态测试、12项记忆测试、分类语言流利性测试和一项修改后的15项波士顿命名测试。A测定血清BDNF水平和载脂蛋白E(APOE)等位基因状态。对AD患者进行前瞻性随访。根据MMSE评分的差异,将这些患者分为快速下降型(下降≥3/y)和缓慢下降型(MMSE下降<3/y)。进行Logistic回归以检查血清BDNF水平和其他因素对AD患者缓慢下降的可能性的影响。Pearson相关性用于估计血清BDNF水平与神经心理测试分数之间的关系。结果:在包含血清BDNF水平、年龄、性别、APOE4携带者状态、教育水平和基线MMSE评分的逻辑回归模型中,AD组血清BDNF含量越高,认知能力下降的速度越慢。血清BDNF水平与多项神经心理测试结果呈正相关。结论:BDNF是AD进展的保护因子,可能在AD病理和临床表现之间建立联系中发挥作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of the Chinese Medical Association
Journal of the Chinese Medical Association MEDICINE, GENERAL & INTERNAL-
CiteScore
6.20
自引率
13.30%
发文量
320
审稿时长
15.5 weeks
期刊介绍: Journal of the Chinese Medical Association, previously known as the Chinese Medical Journal (Taipei), has a long history of publishing scientific papers and has continuously made substantial contribution in the understanding and progress of a broad range of biomedical sciences. It is published monthly by Wolters Kluwer Health and indexed in Science Citation Index Expanded (SCIE), MEDLINE®, Index Medicus, EMBASE, CAB Abstracts, Sociedad Iberoamericana de Informacion Cientifica (SIIC) Data Bases, ScienceDirect, Scopus and Global Health. JCMA is the official and open access journal of the Chinese Medical Association, Taipei, Taiwan, Republic of China and is an international forum for scholarly reports in medicine, surgery, dentistry and basic research in biomedical science. As a vehicle of communication and education among physicians and scientists, the journal is open to the use of diverse methodological approaches. Reports of professional practice will need to demonstrate academic robustness and scientific rigor. Outstanding scholars are invited to give their update reviews on the perspectives of the evidence-based science in the related research field. Article types accepted include review articles, original articles, case reports, brief communications and letters to the editor
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