Crosstalk between peripheral immunity and central nervous system in Alzheimer’s disease

IF 3.7 4区医学 Q2 CELL BIOLOGY

Cellular immunology Pub Date : 2023-09-01 DOI:10.1016/j.cellimm.2023.104743

Hanchen Yang , Qi Qin , Meng Wang , Yunsi Yin , Ruiyang Li , Yi Tang

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Abstract

The significance of peripheral immunity in the pathogenesis and progression of Alzheimer’s diseases (AD) has been recognized. Brain-infiltrated peripheral immune components transporting across the blood–brain barrier (BBB) may reshape the central immune environment. However, mechanisms of how these components open the BBB for AD occurrence and development and correlations between peripheral and central immunity have not been fully explored. Herein, we formulate a hypothesis whereby peripheral immunity as a critical factor allows AD to progress. Peripheral central immune cell crosstalk is associated with early AD pathology and related risk factors. The damaged BBB permits peripheral immune cells to enter the central immune system to deprive its immune privilege promoting the progression toward developing AD. This review summarizes the influences of risk factors on peripheral immunity, alongside their functions, highlighting the concept of peripheral and central immunity as an integrated system in AD pathogenesis, which has received scant attention before.

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阿尔茨海默病中外周免疫与中枢神经系统的串扰

外周免疫在阿尔茨海默病（AD）的发病机制和进展中的意义已被公认。脑浸润的外周免疫成分通过血脑屏障（BBB）转运可能重塑中枢免疫环境。然而，这些成分如何打开AD发生和发展的血脑屏障的机制以及外周免疫和中枢免疫之间的相关性尚未得到充分探索。在此，我们提出了一个假设，即外周免疫作为一个关键因素可以使AD发展。外周中枢免疫细胞串扰与早期AD病理学及相关危险因素有关。受损的血脑屏障允许外周免疫细胞进入中枢免疫系统，剥夺其免疫特权，从而促进AD的发展。本文综述了危险因素对外周免疫的影响及其功能，强调了外周免疫和中枢免疫作为AD发病机制中的一个综合系统的概念，这在以前很少受到关注。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular immunology 生物-免疫学

CiteScore

8.20

自引率

2.30%

发文量

102

审稿时长

30 days

期刊介绍： Cellular Immunology publishes original investigations concerned with the immunological activities of cells in experimental or clinical situations. The scope of the journal encompasses the broad area of in vitro and in vivo studies of cellular immune responses. Purely clinical descriptive studies are not considered. Research Areas include: • Antigen receptor sites • Autoimmunity • Delayed-type hypersensitivity or cellular immunity • Immunologic deficiency states and their reconstitution • Immunologic surveillance and tumor immunity • Immunomodulation • Immunotherapy • Lymphokines and cytokines • Nonantibody immunity • Parasite immunology • Resistance to intracellular microbial and viral infection • Thymus and lymphocyte immunobiology • Transplantation immunology • Tumor immunity.