An Update on the Diagnosis and Management of Calcium Crystal Disease.

IF 5.7 2区 医学 Q1 RHEUMATOLOGY
Current Rheumatology Reports Pub Date : 2023-08-01 Epub Date: 2023-05-30 DOI:10.1007/s11926-023-01106-9
Rachael Flood, John Stack, Geraldine McCarthy
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引用次数: 0

Abstract

Purpose of review: This article aims to review the challenges to diagnosis and management of calcium crystal deposition diseases and evaluate the literature published over the past 3 years.

Recent findings: The awaited development of classification criteria is an essential step in the progression of calcium crystal deposition disease clinical research. There have been recent improvements in the accuracy of imaging for the diagnosis of crystal deposition diseases with published definitions of characteristic features. Factors associated with acute flares of disease have been identified and an association with increased cardiovascular risk has been demonstrated. Targeted treatment options for calcium crystal diseases remain elusive. However, there have been advances in understanding the molecular mechanisms of disease revealing potential targets for future drug development. Calcium-crystal deposition diseases are increasing in incidence and prevalence as populations age and continue to associate with a high burden of disability. Despite this, calcium crystal deposition disease remains under-studied with a paucity of evidence-based treatment guidelines.

钙结晶病诊断和管理的最新进展。
综述目的:本文旨在回顾钙晶体沉积症的诊断和管理所面临的挑战,并对过去三年发表的文献进行评估:期待已久的分类标准的制定是钙晶体沉积症临床研究进展中必不可少的一步。最近,随着特征定义的公布,影像学诊断晶体沉积疾病的准确性有所提高。与疾病急性发作相关的因素已经确定,与心血管风险增加的关联也已得到证实。钙晶体疾病的靶向治疗方案仍然遥遥无期。不过,在了解疾病的分子机制方面取得了进展,揭示了未来药物开发的潜在目标。随着人口老龄化的加剧,钙晶体沉积疾病的发病率和流行率也在不断上升,并继续带来高昂的残疾负担。尽管如此,对钙晶体沉积疾病的研究仍然不足,而且缺乏循证治疗指南。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
11.20
自引率
0.00%
发文量
41
期刊介绍: This journal aims to review the most important, recently published research in the field of rheumatology. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care and prevention of rheumatologic conditions. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas such as the many forms of arthritis, osteoporosis and metabolic bone disease, and systemic lupus erythematosus. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also occasionally provided.
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