Early Detection of Dementia using Risk Classification in MCI: Outcomes of Shanghai Mild Cognitive Impairment Cohort Study.

IF 1.8 4区 医学 Q3 CLINICAL NEUROLOGY
Bin Zhou, Qianhua Zhao, Shinsuke Kojima, Ding Ding, Satoshi Higashide, Masanori Fukushima, Zhen Hong
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Abstract

Introduction: The purpose of this study is to identify the risk factors and risk classification associated with the conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD) dementia to facilitate early intervention and the design of clinical trials for AD.

Methods: The study comprised a prospective cohort study of 400 subjects with MCI who had annual follow-ups for 3 years.

Results: During an average follow-up period of 3.5 years, 109 subjects were diagnosed with all cause of dementia, of whom 104 subjects converted to Alzheimer's dementia and 5 subjects converted to other types of dementia. The cumulative conversion rate was 5.5% (95% CI: 3.4, 8.6), 16.3% (95% CI: 12.9, 21.1), and 31.0% (95% CI: 25.4, 36.5) in each of the first 3 follow-up years, respectively. The factors associated with a greater risk of conversion from MCI to AD included smoking status, ApoE4 carrier status, right hippocampal volume (rt. HV), left temporal lobe volume, and scores on the Revised Chinese version of the Alzheimer's Disease Assessment Scale-Cognitive Subscale 13 (ADAS-Cog-C). The risk classification of the ADAS-Cog-C or Preclinical Alzheimer Cognitive Composite (PACC) score combined with the rt. HV showed a conversion difference among the groups at every annual follow-up.

Conclusion: A simple risk classification using the rt. HV and neuropsychological test scores, including those from the ADAS-Cog-C and PACC, could be a practicable and efficient approach to indentify individuals at risk of all-cause dementia.

早期发现MCI痴呆的风险分类:上海轻度认知障碍队列研究的结果。
前言:本研究旨在确定轻度认知障碍(MCI)向阿尔茨海默病(AD)痴呆转化的相关危险因素和风险分类,为早期干预和AD临床试验设计提供依据。方法:对400名轻度认知障碍患者进行了为期3年的年度随访。结果:在平均3.5年的随访期间,109名受试者被诊断为痴呆的所有原因,其中104名受试者转化为阿尔茨海默氏痴呆,5名受试者转化为其他类型的痴呆。在前3年随访中,累计转换率分别为5.5% (95% CI: 3.4, 8.6), 16.3% (95% CI: 12.9, 21.1)和31.0% (95% CI: 25.4, 36.5)。与MCI转化为AD的高风险相关的因素包括吸烟状况、ApoE4携带者状态、右侧海马体积(rt. HV)、左侧颞叶体积以及修订中文版阿尔茨海默病评估量表-认知子量表13 (ADAS-Cog-C)的得分。在每年的随访中,ADAS-Cog-C或临床前阿尔茨海默认知复合(PACC)评分与rt. HV的风险分类显示各组之间的转换差异。结论:使用rt. HV和神经心理学测试分数(包括ADAS-Cog-C和PACC的分数)进行简单的风险分类,可能是识别全因痴呆风险个体的一种可行且有效的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current Alzheimer research
Current Alzheimer research 医学-神经科学
CiteScore
4.00
自引率
4.80%
发文量
64
审稿时长
4-8 weeks
期刊介绍: Current Alzheimer Research publishes peer-reviewed frontier review, research, drug clinical trial studies and letter articles on all areas of Alzheimer’s disease. This multidisciplinary journal will help in understanding the neurobiology, genetics, pathogenesis, and treatment strategies of Alzheimer’s disease. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, molecular, and animal models. The journal also covers original articles on recent research in fast emerging areas of molecular diagnostics, brain imaging, drug development and discovery, and clinical aspects of Alzheimer’s disease. Manuscripts are encouraged that relate to the synergistic mechanism of Alzheimer''s disease with other dementia and neurodegenerative disorders. Book reviews, meeting reports and letters-to-the-editor are also published. The journal is essential reading for researchers, educators and physicians with interest in age-related dementia and Alzheimer’s disease. Current Alzheimer Research provides a comprehensive ''bird''s-eye view'' of the current state of Alzheimer''s research for neuroscientists, clinicians, health science planners, granting, caregivers and families of this devastating disease.
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