Quantitative analysis using intraoperative contrast-enhanced ultrasound in adult-type diffuse gliomas with isocitrate dehydrogenase mutations: association between hemodynamics and molecular features.

IF 2.4 3区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Ultrasonography Pub Date : 2023-10-01 Epub Date: 2023-07-17 DOI:10.14366/usg.23031

Xiandi Zhang, Zhifeng Shi, Yuanxin Xie, Yong Wang, Chao Shen, Zengxin Qi, Liqiong Zhang, Bojie Yang, Jinhua Yu, Hong Ding

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引用次数: 0

Abstract

Purpose: The relationship between contrast-enhanced ultrasound (CEUS) hemodynamics and the molecular biomarkers of adult-type diffuse gliomas, particularly isocitrate dehydrogenase (IDH), remains unclear. This study was conducted to provide a comprehensive description of the vascularization of adult-type diffuse gliomas using quantitative indicators. Additionally, it was designed to identify any variables with the potential to intraoperatively predict IDH mutation status.

Methods: This prospective study enrolled patients with adult-type diffuse gliomas between November 2021 and September 2022. Intraoperative CEUS was performed, and CEUS videos were recorded for 90-second periods. Hemodynamic parameters, including the peak enhancement (PE) difference, were calculated based on the time-intensity curve of the region of interest. A differential analysis was performed on the CEUS parameters with respect to molecular biomarkers and grades. Receiver operating characteristic curves for various parameters were analyzed to evaluate the ability of those parameters to predict IDH mutation status.

Results: Sixty patients with adult-type diffuse gliomas were evaluated. All hemodynamic parameters, apart from rising time, demonstrated significant differences between IDH-mutant and IDH-wildtype adult-type diffuse gliomas. The PE difference emerged as the optimal indicator for differentiating between IDH-wildtype and IDH-mutant gliomas, with an area under the curve of 0.958 (95% confidence interval, 0.406 to 0.785). Additionally, the hemodynamic parameters revealed significant differences across both grades and types of adult-type diffuse gliomas.

Conclusion: Hemodynamic parameters can be used intraoperatively to effectively distinguish between IDHwildtype and IDH-mutant adult-type diffuse gliomas. Additionally, quantitative CEUS equips neurosurgeons with dynamic perfusion information for various types and grades of adult-type diffuse gliomas.

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术中超声造影定量分析伴有异柠檬酸脱氢酶突变的成人型弥漫性胶质瘤：血流动力学和分子特征之间的关系。

目的：超声造影（CEUS）血流动力学与成人型弥漫性胶质瘤的分子生物标志物，特别是异柠檬酸脱氢酶（IDH）之间的关系尚不清楚。本研究旨在使用定量指标对成人型弥漫性胶质瘤的血管形成进行全面描述。此外，它被设计用于识别任何有可能在手术中预测IDH突变状态的变量。方法：这项前瞻性研究纳入了2021年11月至2022年9月期间的成人型弥漫性胶质瘤患者。术中进行了CEUS，并记录了90秒的CEUS视频。根据感兴趣区域的时间-强度曲线计算血液动力学参数，包括峰值增强（PE）差异。对分子生物标志物和等级的CEUS参数进行了差异分析。分析了各种参数的受试者工作特性曲线，以评估这些参数预测IDH突变状态的能力。结果：对60例成人型弥漫性胶质瘤患者进行了评价。除上升时间外，所有血液动力学参数均显示IDH突变型和IDH野生型成人弥漫性胶质瘤之间存在显著差异。PE差异是区分IDH野生型和IDH突变型胶质瘤的最佳指标，曲线下面积为0.958（95%置信区间，0.406至0.785）。此外，血液动力学参数显示，成人型弥漫性胶质瘤的级别和类型存在显著差异。结论：血液动力学参数可用于术中有效区分IDH野生型和IDH突变成人型弥漫性胶质瘤。此外，定量CEUS为神经外科医生提供了各种类型和级别的成人型弥漫性胶质瘤的动态灌注信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ultrasonography Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

5.10

自引率

6.50%

发文量

审稿时长

15 weeks

期刊介绍： Ultrasonography, the official English-language journal of the Korean Society of Ultrasound in Medicine (KSUM), is an international peer-reviewed academic journal dedicated to practice, research, technology, and education dealing with medical ultrasound. It is renamed from the Journal of Korean Society of Ultrasound in Medicine in January 2014, and published four times per year: January 1, April 1, July 1, and October 1. Original articles, technical notes, topical reviews, perspectives, pictorial essays, and timely editorial materials are published in Ultrasonography covering state-of-the-art content. Ultrasonography aims to provide updated information on new diagnostic concepts and technical developments, including experimental animal studies using new equipment in addition to well-designed reviews of contemporary issues in patient care. Along with running KSUM Open, the annual international congress of KSUM, Ultrasonography also serves as a medium for cooperation among physicians and specialists from around the world who are focusing on various ultrasound technology and disease problems and relevant basic science.