Point prevalence probing of antimicrobial prescription patterns from a developing country.

IF 4.2 2区 医学 Q1 INFECTIOUS DISEASES
Nazia Khursheed, Qadeer Ahsan, Salima Rattani, Madeeha Fatima, Ali Raza, Saba Tariq, Tauqeer Mustafa, Kamran Ahmed, Sadia Iqbal, Sibgha Zulfiqar, Syed Masroor Ahmed, Ghulam Fatima, Shehzad Akbar Khan, Farman Ullah, Rana Altaf Ahmed, Saba Jamal
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引用次数: 0

Abstract

Background: Irrational use of antibiotics intensifies resistance and jeopardizes advances made in modern medicine. We aimed to conduct a baseline gap analysis survey on antibiotic prescription practices across Pakistan.

Research design and methods: This multi-centered cross-sectional survey was conducted at six public sector tertiary care hospitals from February 2021 to March 2021. Data related to various variables including hospital infrastructure, policies and practices, monitoring and feedback, and epidemiological, clinical, and antibiotic prescription for surveyed patients was collected using World Health Organization (WHO) Point Prevalence Survey (PPS) methodology.

Results: In a survey of 837 inpatients, 78.5% were prescribed antibiotics. Most commonly prescribed antimicrobial was ceftriaxone (21.7%), followed by metronidazole (17.3%), cefoperazone-sulbactam (8.4%), amoxicillin-clavulanate (6.3%), and piperacillin/tazobactam (5.9%). Surgical prophylaxis (36.7%) and community-acquired infections (24.7%) were the main reasons for antibiotic prescriptions. Single antibiotics were given to 46.7% of patients, 39.9% received a combination of two antibiotics, and 12.5% were prescribed three or more antibiotics. Among six hospitals surveyed, two had drug and therapeutic committees, three had infection prevention and control committees, and one had an antibiotic formulary.

Conclusion: Findings demonstrate high consumption of broad-spectrum antimicrobials and emphasize the importance of expanding antimicrobial stewardship programs among hospitals. Mentoring clinical teams could help rationalize antimicrobial use.

发展中国家抗菌药物处方模式的点流行率调查。
背景:抗生素的不合理使用加剧了耐药性,危及现代医学的进步。我们旨在对巴基斯坦各地的抗生素处方做法进行基线差距分析调查。研究设计和方法:这项多中心的横断面调查于2021年2月至2021年3月在六家公立三级护理医院进行。使用世界卫生组织(世界卫生组织)点流行率调查(PPS)方法收集与各种变量相关的数据,包括医院基础设施、政策和实践、监测和反馈,以及受访患者的流行病学、临床和抗生素处方。结果:在对837名住院患者的调查中,78.5%的患者服用了抗生素。最常用的抗菌药物是头孢曲松(21.7%),其次是甲硝唑(17.3%)、头孢哌酮-舒巴坦(8.4%)、阿莫西林-克拉维酸盐(6.3%)和哌拉西林/他唑巴坦(5.9%)。手术预防(36.7%)和社区获得性感染(24.7%)是开具抗菌药物处方的主要原因。46.7%的患者服用单一抗生素,39.9%的患者服用两种抗生素的组合,12.5%的患者服用三种或三种以上抗生素。在接受调查的六家医院中,两家有药物和治疗委员会,三家有感染预防和控制委员会,一家有抗生素处方。结论:研究结果表明,广谱抗菌药物的消费量很高,并强调了在医院中扩大抗菌药物管理计划的重要性。指导临床团队可以帮助合理使用抗菌药物。
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来源期刊
CiteScore
11.20
自引率
0.00%
发文量
66
审稿时长
4-8 weeks
期刊介绍: Expert Review of Anti-Infective Therapy (ISSN 1478-7210) provides expert reviews on therapeutics and diagnostics in the treatment of infectious disease. Coverage includes antibiotics, drug resistance, drug therapy, infectious disease medicine, antibacterial, antimicrobial, antifungal and antiviral approaches, and diagnostic tests.
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