Effects of Sublingual Colostrum Application on Oral and Intestinal Flora of Extremely Low Birth Weight Infants.

IF 2 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Endocrine, metabolic & immune disorders drug targets Pub Date : 2024-01-01 DOI:10.2174/1871530323666230913105820

Hua Wang, Qiu-Fang Li, Xin-Fen Xu, Xiao-Li Hu

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Abstract

Background: The aim of this study is to analyze the effects of colostrum application on the establishment of normal flora in the intestinal tracts and oral cavities of extremely low birth weight infants (ELBWI).

Methods: A prospective cohort study design was adopted following the STROBE guidelines (Supplementary File 1). Colostrum was administered immediately after obtaining maternal breast milk using a special sterile cotton swab. There were no specific treatments for infants who did not receive colostrum. This experiment was completed on day 5 post-birth and the patients were divided into the colostrum and control groups, corresponding to whether or not colostrum was administered. Throat swabs and stool samples were collected on days 1 and 5 post-birth.

Results: Using the conventional bacteria cultivation technique, the detection rate of bacteria in 98 cases of meconium at birth was 15.31%. On day 5, the detection rates of Staphylococcus in the colostrum and control groups were 36.54% and 34.78%, with no significant difference between them (P = 0.856), and that of Enterococcus was 26.92% and 13.04%, respectively, with no statistically significant difference (P = 0.089). Likewise, at birth, the detection rate of bacteria in 98 cases of throat swabs was 27.55%. On day 5, the detection rate of Streptococcus in the colostrum and control groups was 78.85% and 50.00%, respectively, recording a statistically significant difference this time (P = 0.003).

Conclusion: Colostrum application had limited effects on intestinal flora colonization but contributes to physiological oral flora colonization.

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舌下含服牛初乳对极低出生体重儿口腔和肠道菌群的影响

背景：本研究旨在分析添加初乳对极低出生体重儿（ELBWI）肠道和口腔正常菌群建立的影响：方法：根据 STROBE 指南（补充文件 1），采用前瞻性队列研究设计。在获得母奶后，立即用特制的无菌棉签给婴儿喂食初乳。对未吃到初乳的婴儿没有特殊处理。本实验在婴儿出生后第 5 天完成，根据是否服用初乳将患者分为初乳组和对照组。在出生后第 1 天和第 5 天采集咽拭子和粪便样本：采用常规细菌培养技术，出生时 98 例胎粪中的细菌检出率为 15.31%。第 5 天，初乳组和对照组的葡萄球菌检出率分别为 36.54% 和 34.78%，差异无统计学意义（P = 0.856）；肠球菌检出率分别为 26.92% 和 13.04%，差异无统计学意义（P = 0.089）。同样，在出生时，98 例咽拭子的细菌检出率为 27.55%。第 5 天，牛初乳组和对照组的链球菌检出率分别为 78.85% 和 50.00%，差异有统计学意义（P = 0.003）：结论：牛初乳对肠道菌群定植的影响有限，但有助于口腔菌群的生理性定植。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrine, metabolic & immune disorders drug targets ENDOCRINOLOGY & METABOLISMIMMUNOLOGY-IMMUNOLOGY

CiteScore

4.60

自引率

5.30%

发文量

217

期刊介绍： Aims & Scope This journal is devoted to timely reviews and original articles of experimental and clinical studies in the field of endocrine, metabolic, and immune disorders. Specific emphasis is placed on humoral and cellular targets for natural, synthetic, and genetically engineered drugs that enhance or impair endocrine, metabolic, and immune parameters and functions. Moreover, the topics related to effects of food components and/or nutraceuticals on the endocrine-metabolic-immune axis and on microbioma composition are welcome.