IL-10 Polymorphism and Breast Cancer Risk in Georgian Women: A Case-Control Study.

IF 1.2 Q4 GENETICS & HEREDITY
Saba Ahmadi, Sandro Surmava, Eka Kvaratskhelia, Elene Abzianidze, Ketevani Kankava
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Abstract

Background  Interleukin-10 (IL-10) is a cytokine with a vast variety of functions, but its role in cancer development and progression is not yet clear. It is involved in two of the hallmarks of cancer: vascularization and immune modulation. IL-10 inhibits angiogenesis and hence is antitumorigenic. But it also can suppress the immune system and be tumorigenic. Objective  Evaluating the role of IL-10 (-1082 A/G) gene promoter single-nucleotide polymorphism (SNP) in breast cancer susceptibility and progression in Georgian women. Methods  A case-control study was performed on a total of 128 women, with 64 of them being histologically confirmed to have breast cancer and 64 healthy controls. SNP genotyping was performed with TaqMan assay with real-time polymerase chain reaction. And pathology report, containing proliferative activity and breast cancer hormonal status, was obtained after surgery of the case individuals. Statistical analysis was done to investigate the significance of data obtained from genotyping and histology reports. Results  Statistical analysis revealed that the difference in frequency of genotypes was not statistically significant between cases and controls (chi-square = 0.5812, p  = 0.7478). The comparison of proliferative activity of cases with AA genotypes and AG/GG genotypes showed no statistical difference ( t  = 0.2575, p  = 0.7980). Although when put into a plot (box and whiskers), patients with AG/GG genotype have outliers with very high proliferative activity. Conclusion  This study shows that -1082 A/G SNP in the promoter region of the IL-10 gene is not associated with breast cancer risk in Georgian women.

Abstract Image

Abstract Image

IL-10多态性与格鲁吉亚妇女乳腺癌风险:一项病例对照研究
白细胞介素-10 (IL-10)是一种具有多种功能的细胞因子,但其在癌症发生和进展中的作用尚不清楚。它参与了癌症的两个特征:血管化和免疫调节。IL-10抑制血管生成,因此具有抗肿瘤作用。但它也能抑制免疫系统并致瘤。目的探讨IL-10 (-1082 A/G)基因启动子单核苷酸多态性(SNP)在格鲁吉亚妇女乳腺癌易感性和进展中的作用。方法采用病例对照研究方法,对128名妇女进行病例对照研究,其中组织学确诊乳腺癌64例,健康对照64例。实时聚合酶链反应TaqMan法进行SNP基因分型。并获得病例个体术后的病理报告,包括增殖活动和乳腺癌激素状况。对基因分型和组织学报告所得数据进行统计学分析。结果病例与对照组基因型频率差异无统计学意义(χ 2 = 0.5812, p = 0.7478)。AA基因型与AG/GG基因型患者的增殖活性比较,差异无统计学意义(t = 0.2575, p = 0.7980)。虽然当放入图(盒状和须状)时,AG/GG基因型患者具有非常高的增殖活性的异常值。结论本研究表明,IL-10基因启动子区域的-1082 A/G SNP与格鲁吉亚妇女乳腺癌风险无关。
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来源期刊
Global Medical Genetics
Global Medical Genetics GENETICS & HEREDITY-
自引率
11.80%
发文量
30
审稿时长
14 weeks
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