Synchrotron Imaging Assessment of Bone Quality.

IF 0.8 Q4 ENDOCRINOLOGY & METABOLISM

Clinical Reviews in Bone and Mineral Metabolism Pub Date : 2016-01-01 Epub Date: 2016-09-07 DOI:10.1007/s12018-016-9223-3

Shaocheng Ma, Oliver Boughton, Angelo Karunaratne, Andi Jin, Justin Cobb, Ulrich Hansen, Richard Abel

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Abstract

Bone is a complex hierarchical structure, and its principal function is to resist mechanical forces and fracture. Bone strength depends not only on the quantity of bone tissue but also on the shape and hierarchical structure. The hierarchical levels are interrelated, especially the micro-architecture, collagen and mineral components; hence, analysis of their specific roles in bone strength and stiffness is difficult. Synchrotron imaging technologies including micro-CT and small/wide angle X-ray scattering/diffraction are becoming increasingly popular for studying bone because the images can resolve deformations in the micro-architecture and collagen-mineral matrix under in situ mechanical loading. Synchrotron cannot be directly applied in vivo due to the high radiation dose but will allow researchers to carry out systematic multifaceted studies of bone ex vivo. Identifying characteristics of aging and disease will underpin future efforts to generate novel devices and interventional therapies for assessing and promoting healthy aging. With our own research work as examples, this paper introduces how synchrotron imaging technology can be used with in situ testing in bone research.

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同步加速器成像评估骨骼质量。

骨骼是一种复杂的层次结构，其主要功能是抵抗机械力和骨折。骨强度不仅取决于骨组织的数量，还取决于骨组织的形状和层次结构。各层次之间相互关联，尤其是微结构、胶原蛋白和矿物质成分，因此很难分析它们在骨强度和刚度中的具体作用。同步加速器成像技术（包括微型计算机断层扫描和小/广角 X 射线散射/衍射）在研究骨质方面越来越受欢迎，因为这些图像可以解析原位机械加载下微观结构和胶原-矿物基质的变形。由于辐射剂量大，同步加速器不能直接应用于体内，但研究人员可以利用它对体内外的骨骼进行系统的多方面研究。确定衰老和疾病的特征将为未来开发新型设备和干预疗法提供支持，以评估和促进健康衰老。本文将以我们自己的研究工作为例，介绍同步辐射成像技术如何与骨骼研究中的原位测试相结合。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Reviews in Bone and Mineral Metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

3.10

自引率

0.00%

发文量

期刊介绍： Clinical Reviews in Bone and Mineral Metabolism is an international review journal aimed at integrating new information from both basic and clinical science into the context of clinical practice in the wide field of Bone and Mineral Metabolism. Although one purpose of the journal is to deal with the well-known classical aspects of bone and mineral physiology, the journal’s unique character is to highlight information about the advancing field of molecular medicine, which now finds linkages between this classical field and disease states that in the past were considered distinct. For example, cardiovascular disease and osteoporosis share many biochemical pathways. New molecular tools show common pathways with bone physiology and obesity, diabetes mellitus, and energy metabolism. The focus on the novel is a major aspect of this journal’s purpose. The rapid developments in the field needs to be represented in a comprehensive way in order to keep students, clinicians and researchers up-to date. In order to assure that all latest developments are covered, the journal publishes, not only, unsolicited reviews, but also invited reviews on most important topics as well.