Guillain-Barré syndrome in patients dying with COVID-19 in Italy: a retrospective study.

IF 1.1 4区医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Annali dell'Istituto superiore di sanita Pub Date : 2023-07-01 DOI:10.4415/ANN_23_03_04

Elisa Colaizzo, Maria Puopolo, Dorina Tiple, Luana Vaianella, Nicola Vanacore, Alberto Milanese, Luigi Palmieri, Cinzia Lo Noce, Marco Canevelli, Alessia Perna, Graziano Onder

{"title":"Guillain-Barré syndrome in patients dying with COVID-19 in Italy: a retrospective study.","authors":"Elisa Colaizzo, Maria Puopolo, Dorina Tiple, Luana Vaianella, Nicola Vanacore, Alberto Milanese, Luigi Palmieri, Cinzia Lo Noce, Marco Canevelli, Alessia Perna, Graziano Onder","doi":"10.4415/ANN_23_03_04","DOIUrl":null,"url":null,"abstract":"Introduction: We presented a four-case series of COVID-19 related deaths occurred in patients with Guillain-Barré syndrome (GBS) between February 2020 and January 2022 in Italy.Methods: They were extracted from 8,436 medical charts of COVID-19 patients dying. All cases, ranged 48-73 years, showed classical GBS clinical onset - limb weakness, sensory deficits, hypoareflexia - and three of them were admitted in intensive care unit (ICU) for ventilator support.Results: The cerebrospinal fluid showing albumin-cytological dissociation was performed in two cases. Nerve conduction studies supported the diagnosis in all cases. Interstitial pneumonia was documented by chest X-rays or CT scans in all cases: they were treated with intravenous immunoglobulin (IVIg) and the drugs used for COVID-19 infection.Conclusions: Although the mechanism of GBS onset is still unclear in COVID-19, fatal cases may be more frequent than other virus-related GBS, so that strictly monitoring in high-risk patients could dramatically decrease the mortality of GBS.","PeriodicalId":8246,"journal":{"name":"Annali dell'Istituto superiore di sanita","volume":"59 3","pages":"194-198"},"PeriodicalIF":1.1000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annali dell'Istituto superiore di sanita","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4415/ANN_23_03_04","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: We presented a four-case series of COVID-19 related deaths occurred in patients with Guillain-Barré syndrome (GBS) between February 2020 and January 2022 in Italy.

Methods: They were extracted from 8,436 medical charts of COVID-19 patients dying. All cases, ranged 48-73 years, showed classical GBS clinical onset - limb weakness, sensory deficits, hypoareflexia - and three of them were admitted in intensive care unit (ICU) for ventilator support.

Results: The cerebrospinal fluid showing albumin-cytological dissociation was performed in two cases. Nerve conduction studies supported the diagnosis in all cases. Interstitial pneumonia was documented by chest X-rays or CT scans in all cases: they were treated with intravenous immunoglobulin (IVIg) and the drugs used for COVID-19 infection.

Conclusions: Although the mechanism of GBS onset is still unclear in COVID-19, fatal cases may be more frequent than other virus-related GBS, so that strictly monitoring in high-risk patients could dramatically decrease the mortality of GBS.

查看原文本刊更多论文

意大利新冠肺炎死亡患者的格林-巴利综合征：一项回顾性研究。

简介：我们介绍了2020年2月至2022年1月期间在意大利发生的格林-巴利综合征（GBS）患者中与新冠肺炎相关的四个病例系列。方法：从8436例新冠肺炎死亡患者病历中提取。所有病例年龄在48-73岁之间，均表现出典型的GBS临床发作——肢体无力、感觉缺陷、灵活性减退——其中三人入住重症监护室（ICU）接受呼吸机支持。结果：两例脑脊液显示白蛋白脱落。神经传导研究支持所有病例的诊断。在所有病例中，通过胸部X光或CT扫描记录了间质性肺炎：他们接受了静脉注射免疫球蛋白（IVIg）和用于治疗新冠肺炎感染的药物治疗。结论：尽管新冠肺炎GBS发病机制尚不清楚，但致死病例可能比其他病毒相关GBS更频繁，因此对高危患者进行严格监测可以显著降低GBS的死亡率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Annali dell'Istituto superiore di sanita PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

3.80

自引率

4.80%

发文量

审稿时长

>12 weeks

期刊介绍： Annali dell’Istituto Superiore di Sanità is a peer reviewed quarterly science journal which publishes research articles in biomedicine, translational research and in many other disciplines of the health sciences. The journal includes the following material: original articles, reviews, commentaries, editorials, brief and technical notes, book reviews. The publication of Monographic Sections has been discontinued. In case you wish to present a small number of coordinated contributions on specific themes concerning priorities in public health, please contact the Editorial office. The journal is in English.