DNA methylation of HOX genes and its clinical implications in cancer

IF 2.8 4区医学 Q2 PATHOLOGY

Experimental and molecular pathology Pub Date : 2023-09-13 DOI:10.1016/j.yexmp.2023.104871

Xin Hu , Yong Wang , Xiaoyu Zhang , Chensheng Li , Xikun Zhang , Dongxia Yang , Yuanyuan Liu , Lianlian Li

引用次数: 0

Abstract

Homeobox (HOX) genes encode highly conserved transcription factors that play vital roles in embryonic development. DNA methylation is a pivotal regulatory epigenetic signaling mark responsible for regulating gene expression. Abnormal DNA methylation is largely associated with the aberrant expression of HOX genes, which is implicated in a broad range of human diseases, including cancer. Numerous studies have clarified the mechanisms of DNA methylation in both physiological and pathological processes. In this review, we focus on how DNA methylation regulates HOX genes and briefly discuss drug development approaches targeting these mechanisms.

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HOX基因的DNA甲基化及其在癌症中的临床意义

同源盒(HOX)基因编码高度保守的转录因子，在胚胎发育中起着至关重要的作用。DNA甲基化是调控基因表达的关键调控表观遗传信号标记。异常DNA甲基化在很大程度上与HOX基因的异常表达有关，这与包括癌症在内的多种人类疾病有关。大量的研究已经阐明了DNA甲基化在生理和病理过程中的机制。在这篇综述中，我们将重点关注DNA甲基化如何调节HOX基因，并简要讨论针对这些机制的药物开发方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental and molecular pathology 医学-病理学

CiteScore

8.90

自引率

0.00%

发文量

审稿时长

11.5 weeks

期刊介绍： Under new editorial leadership, Experimental and Molecular Pathology presents original articles on disease processes in relation to structural and biochemical alterations in mammalian tissues and fluids and on the application of newer techniques of molecular biology to problems of pathology in humans and other animals. The journal also publishes selected interpretive synthesis reviews by bench level investigators working at the "cutting edge" of contemporary research in pathology. In addition, special thematic issues present original research reports that unravel some of Nature''s most jealously guarded secrets on the pathologic basis of disease. Research Areas include: Stem cells; Neoangiogenesis; Molecular diagnostics; Polymerase chain reaction; In situ hybridization; DNA sequencing; Cell receptors; Carcinogenesis; Pathobiology of neoplasia; Complex infectious diseases; Transplantation; Cytokines; Flow cytomeric analysis; Inflammation; Cellular injury; Immunology and hypersensitivity; Athersclerosis.