Loss of aquaporin-1 expression is associated with worse clinical outcomes in clear cell renal cell carcinoma: an immunohistochemical study.

IF 1.7 Q3 PATHOLOGY

Journal of Pathology and Translational Medicine Pub Date : 2023-07-01 DOI:10.4132/jptm.2023.06.17

Seokhyeon Lee, Bohyun Kim, Minsun Jung, Kyung Chul Moon

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Abstract

Background: Aquaporin (AQP) expression has been investigated in various malignant neoplasms, and the overexpression of AQP is related to poor prognosis in some malignancies. However, the expression of AQP protein in clear cell renal cell carcinoma (ccRCC) has not been extensively investigated by immunohistochemistry with large sample size.

Methods: We evaluated the AQP expression in 827 ccRCC with immunohistochemical staining in tissue microarray blocks and classified the cases into two categories, high and low expression.

Results: High expression of aquaporin-1 (AQP1) was found in 320 cases (38.7%), but aquaporin-3 was not expressed in ccRCC. High AQP1 expression was significantly related to younger age, low TNM stage, low World Health Organization/International Society of Urologic Pathology nuclear grade, and absence of distant metastasis. Furthermore, high AQP1 expression was also significantly associated with longer overall survival (OS; p<.001) and progression-specific survival (PFS; p<.001) and was an independent predictor of OS and PFS in ccRCC.

Conclusions: Our study revealed the prognostic significance of AQP1 protein expression in ccRCC. These findings could be applied to predict the prognosis of ccRCC.

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透明细胞肾细胞癌中水通道蛋白-1表达缺失与较差的临床结果相关:一项免疫组织化学研究

背景:研究了水通道蛋白(AQP)在多种恶性肿瘤中的表达，发现AQP过表达与部分恶性肿瘤预后不良有关。然而，AQP蛋白在透明细胞肾细胞癌(ccRCC)中的表达尚未得到大样本免疫组化的广泛研究。方法:采用组织芯片免疫组化染色法检测827例ccRCC AQP的表达，并将其分为高表达和低表达两类。结果:水通道蛋白1 (AQP1)在320例(38.7%)ccRCC中高表达，而水通道蛋白3在ccRCC中未表达。AQP1高表达与年龄小、TNM分期低、世界卫生组织/国际泌尿外科病理学会核分级低、无远处转移相关。此外，AQP1的高表达也与更长的总生存期(OS;结论:我们的研究揭示了AQP1蛋白表达在ccRCC中的预后意义。这些结果可用于预测ccRCC的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Pathology and Translational Medicine PATHOLOGY-

CiteScore

5.00

自引率

4.20%

发文量

审稿时长

14 weeks

期刊介绍： The Journal of Pathology and Translational Medicine is an open venue for the rapid publication of major achievements in various fields of pathology, cytopathology, and biomedical and translational research. The Journal aims to share new insights into the molecular and cellular mechanisms of human diseases and to report major advances in both experimental and clinical medicine, with a particular emphasis on translational research. The investigations of human cells and tissues using high-dimensional biology techniques such as genomics and proteomics will be given a high priority. Articles on stem cell biology are also welcome. The categories of manuscript include original articles, review and perspective articles, case studies, brief case reports, and letters to the editor.