Outcomes of patients with COVID-19 requiring extracorporeal membrane oxygenation and continuous renal replacement therapy in the United States.

IF 1.7 Q3 CRITICAL CARE MEDICINE

Acute and Critical Care Pub Date : 2023-08-01 DOI:10.4266/acc.2023.00115

Carlos R Franco Palacios, Rudiona Hoxhaj, Catlyn Thigpen, Jeffrey Jacob, Atul Bhatnagar, Asif Saberi

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Abstract

Background: Coronavirus disease 2019 (COVID-19) infection is associated with significant morbidity and mortality. Some patients develop severe acute respiratory distress syndrome and kidney failure requiring the combination of extracorporeal membrane oxygenation (ECMO) and continuous renal replacement therapy (CRRT).

Methods: Retrospective cohort study of 127 consecutive patients requiring combined ECMO and CRRT support in intensive care units at an ECMO center in Marietta, GA, United States.

Results: Sixty and 67 patients with and without COVID-19, respectively, required ECMO-CRRT support. After adjusting for confounding variables, patients with COVID-19 had increased mortality at 30 days (hazard ratio [HR], 5.19; 95% confidence interval [CI], 2.51-10.7; P<0.001) and 90 days (HR, 6.23; 95% CI, 2.60-14.9; P<0.001).

Conclusions: In this retrospective study, patients with COVID-19 who required ECMO-CRRT had increased mortality when compared to patients without COVID-19.

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在美国，COVID-19患者需要体外膜氧合和持续肾脏替代治疗的结果

背景:冠状病毒病2019 (COVID-19)感染与显著的发病率和死亡率相关。一些患者出现严重的急性呼吸窘迫综合征和肾衰竭，需要联合体外膜氧合(ECMO)和持续肾替代治疗(CRRT)。方法:回顾性队列研究127例连续患者需要联合ECMO和CRRT支持在重症监护室在Marietta, GA，美国ECMO中心。结果:有COVID-19和无COVID-19的患者分别有60例和67例需要ECMO-CRRT支持。在校正混杂变量后，COVID-19患者在30天的死亡率增加(风险比[HR]， 5.19;95%置信区间[CI]， 2.51-10.7;结论:在这项回顾性研究中，与没有COVID-19的患者相比，需要ECMO-CRRT的COVID-19患者死亡率增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acute and Critical Care CRITICAL CARE MEDICINE-

CiteScore

2.80

自引率

11.10%

发文量

审稿时长

12 weeks