Clinical features and outcomes analysis of Gallbladder neuroendocrine carcinoma.

IF 1.4 4区医学 Q4 ONCOLOGY

Journal of cancer research and therapeutics Pub Date : 2023-08-01 DOI:10.4103/jcrt.jcrt_1959_21

Man Jiang, Yijing Zhang

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引用次数: 1

Abstract

Purpose: Gallbladder neuroendocrine carcinoma (GB-NEC) is an uncommon and highly malignant tumor. This research aimed to investigate the clinical characteristics and prognostic factors of GB-NEC.

Materials and methods: Our survey of case reports from January 2000 to May 2022 screened a total of 84 patients with complete data who received surgical resection for gallbladder NEC. Log-rank generated survival curves using the Kaplan-Meier method for univariate survival analysis. To identify GB-NEC independent prognostic indicators for overall survival (OS), univariate and multivariate Cox proportional hazard analyses were conducted.

Results: These patients consisted of 25 men and 59 women, with an average age of 60 (range 29-85). Patients under 60 years old made up 44% of the population, while patients over 60 made up 56%. Fifty-three tumors were advanced pathologic TNM stage III and IV. After surgery, 44 patients underwent chemotherapy or radiotherapy. The median OS of 84 patients with GB-NEC was 16.8 months. In univariate and multivariate analysis, tumor size (diameter ≥5 cm), TNM tumor stage, and the receipt of postoperative adjuvant chemotherapy are independent factors influencing the prognosis of patients with GB-NEC.

Conclusion: Tumor size (diameter ≥5 cm) and TNM tumor stage were independently related to a shorter OS. An enhanced OS was independently linked to receiving postoperative adjuvant chemotherapy.

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胆囊神经内分泌癌的临床特点及预后分析。

目的:胆囊神经内分泌癌(GB-NEC)是一种少见的恶性肿瘤。本研究旨在探讨GB-NEC的临床特点及预后因素。材料与方法:我们对2000年1月至2022年5月的病例报告进行调查，共筛选了84例资料完整的胆囊NEC手术切除患者。Log-rank生成的生存曲线使用Kaplan-Meier方法进行单变量生存分析。为了确定GB-NEC的总生存(OS)独立预后指标，进行了单因素和多因素Cox比例风险分析。结果:男性25例，女性59例，平均年龄60岁(29-85岁)。60岁以下的患者占总人口的44%，60岁以上的患者占56%。53例肿瘤为晚期病理性TNM III期和IV期。术后44例患者接受化疗或放疗。84例GB-NEC患者的中位OS为16.8个月。在单因素和多因素分析中，肿瘤大小(直径≥5cm)、TNM肿瘤分期、术后接受辅助化疗是影响GB-NEC患者预后的独立因素。结论:肿瘤大小(直径≥5cm)和TNM肿瘤分期与较短的OS独立相关。增强的OS与接受术后辅助化疗独立相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of cancer research and therapeutics ONCOLOGY-

CiteScore

1.80

自引率

15.40%

发文量

299

审稿时长

6 months

期刊介绍： The journal will cover technical and clinical studies related to health, ethical and social issues in field of Medical oncology, radiation oncology, medical imaging, radiation protection, non-ionising radiation, radiobiology. Articles with clinical interest and implications will be given preference.