Epidemiological characteristics and transmissibility of HPV infection: A long-term retrospective study in Hokkien Golden Triangle, China, 2013–2021

IF 3 3区医学 Q2 INFECTIOUS DISEASES

Epidemics Pub Date : 2023-09-01 DOI:10.1016/j.epidem.2023.100707

Jingwen Xu , Guzainuer Abudurusuli , Jia Rui , Zhuoyang Li , Zeyu Zhao , Yilan Xia , Xiaohao Guo , Buasiyamu Abudunaibi , Benhua Zhao , Qiwei Guo , Jing-An Cui , Yulin Zhou , Tianmu Chen

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引用次数: 0

Abstract

Objective

Multiple human papillomavirus (HPV)-associated diseases have put a significant disease burden on the world. Therefore, we conducted a study to explore the epidemiological characteristics of HPV and the transmissibility of its genotypes.

Methods

HPV testing data was collected from Hospital. A transmission dynamics model of HPV was constructed to simulate and compare the transmissibility of different HPV genotypes, which was quantitatively described by the basic reproduction number (R₀).

Results

The collected HPV subjects were mainly from Xiamen City, Zhangzhou City and Quanzhou City, together, they are known as the Hokkien golden triangle. There were variations in the distribution of HPV infections by age groups. Among all HPV genotypes, 13 of them had R₀ > 1, with 10 of them being high-risk types. The top five were HPV56, 18, 58, 52 and 53, among which, HPV56, 18, 58 and 42 were of high risk, whereas HPV53 was not, and the R₀ values for the five were 3.35 (CI: 0.00–9.99), 3.20 (CI: 0.00–6.46), 3.19 (CI: 1.27–6.94), 3.19 (CI: 1.01–8.42) and 2.99 (CI: 0.00–9.39), respectively. In addition, HPV52 had R₀ > 1 for about 51 months, which had the longest duration.

Conclusion

Most high-risk HPV types in the Hokkien golden triangle could transmit among the population. Therefore, there is a need of further optimization for developing HPV vaccines and better detection methods in the region.

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HPV感染的流行病学特征和传播性：2013-2021年中国福建金三角地区的一项长期回顾性研究。

目的：多种人乳头瘤病毒（HPV）相关疾病给世界带来了巨大的疾病负担。因此，我们进行了一项研究，以探讨HPV的流行病学特征及其基因型的传播性。方法：收集医院HPV检测资料。构建了一个HPV的传播动力学模型，以模拟和比较不同HPV基因型的传播性，并用基本繁殖数（R0）定量描述。结果：收集到的HPV受试者主要来自厦门市、漳州市和泉州市，三者合称福建金三角。不同年龄组的HPV感染分布存在差异。在所有HPV基因型中，13种基因型R0>1，其中10种为高危型。前五名分别是HPV56、18、58、52和53，其中，HPV56，18、58和42为高风险，而HPV53不是，五名的R0值分别为3.35（CI:0.00--9.99）、3.20（CI:0.0-6.46）、3.19（CI:1.27-6.94）、3.19%（CI:1.01-8.42）和2.99（CI:0.00-9.39）。此外，HPV52的R0>1持续时间约为51个月，持续时间最长。结论：福建金三角地区大多数高危型HPV可在人群中传播。因此，该地区需要进一步优化开发HPV疫苗和更好的检测方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Epidemics INFECTIOUS DISEASES-

CiteScore

6.00

自引率

7.90%

发文量

审稿时长

140 days

期刊介绍： Epidemics publishes papers on infectious disease dynamics in the broadest sense. Its scope covers both within-host dynamics of infectious agents and dynamics at the population level, particularly the interaction between the two. Areas of emphasis include: spread, transmission, persistence, implications and population dynamics of infectious diseases; population and public health as well as policy aspects of control and prevention; dynamics at the individual level; interaction with the environment, ecology and evolution of infectious diseases, as well as population genetics of infectious agents.