Di‐t‐butyl Dicarbonate

Pub Date : 2001-04-15 DOI:10.1002/047084289X.RD060

M. Wakselman

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引用次数: 2

Abstract

[24424-99-5] C10H18O5 (MW 218.25) InChI = 1S/C10H18O5/c1-9(2,3)14-7(11)13-8(12)15-10(4,5)6/h1-6H3 InChIKey = DYHSDKLCOJIUFX-UHFFFAOYSA-N (efficient tert-butoxycarbonylating agent for amines,1, 2 phenols, and thiols; tert-butoxycarbonylation of alcohols, amides,3 lactams, carbamates4 and NH-pyrroles5 occurs in the presence of 4-dimethylaminopyridine) Alternate Names: di-tert-butyl pyrocarbonate; Boc anhydride; Boc2O. Physical Data: mp 22–24 °C; bp 56–57 °C/0.5 mm Hg; fp 37 °C; d 0.950 g cm−3; nD20 1.4103. Solubility: insol cold H2O; sol most organic solvents such as decalin, toluene, CCl4, THF, dioxane, alcohols, acetone, MeCN, DMF. Form Supplied in: colorless liquid; widely available. Analysis of Reagent Purity: IR 1810 and 1765 cm−1; NMR 1.50 (CCl4). Preparative Method: prepared by the action of Phosgene on potassium tert-butyl carbonate, followed by conversion of the obtained di-tert-butyl tricarbonate under the action of basic catalysts such as 1,4-Diazabicyclo[2.2.2]octane.6 Handling, Storage, and Precautions: the liquid is flammable and must be stored in a refrigerator in the absence of moisture. Do not heat above 80 °C.

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Di量t丁基碳酸氢钠

[24424-99-5] C10H18O5 (MW 218.25) InChI = 1S/C10H18O5/c1-9(2,3)14-7(11)13-8(12)15-10(4,5)6/h1-6H3 InChIKey = DYHSDKLCOJIUFX-UHFFFAOYSA-N(高效叔丁基羰基化剂)醇、酰胺、3内酰胺、氨基甲酸酯和nh -吡咯在4-二甲氨基吡啶的存在下发生叔丁基羰基化。中行酐;Boc2O。物理数据:mp 22-24°C;bp 56-57°C/0.5 mm Hg;fp 37℃;D 0.950 g cm−3;nD20 1.4103。溶解度:在溶胶冷H2O中;溶解大多数有机溶剂，如十氢化萘、甲苯、CCl4、四氢呋喃、二恶烷、醇类、丙酮、MeCN、DMF。供应形式:无色液体;广泛使用。试剂纯度分析:IR 1810和1765 cm−1;核磁共振1.50 (CCl4)。5 .制备方法:由光气作用于碳酸叔丁基钾制备，然后在1,4-重氮杂环[2.2.2]辛烷等碱性催化剂的作用下，将所得的三碳酸二叔丁酯转化处理、储存及注意事项:本品为可燃液体，必须存放在无水分的冰箱中。不要加热超过80°C。

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