Remission of refractory Crohn's disease with anti-IL-12/23 therapy in a patient undergoing hemodialysis: A case report

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-06-14 DOI:10.1111/hdi.13106

Michail Spathakis, Eirini Filidou, George Kolios, Dimitrios Papazoglou, Stergios Vradelis

引用次数: 1

Abstract

Crohn's disease is a relapsing chronic inflammatory condition of the intestine with increasing prevalence around the world. Biologic therapies are currently widely used and have proved safe and effective in treating moderate to severe Crohn's disease. However, contemporary bibliography contains little information about the use of these drugs in patients with end-stage renal disease undergoing hemodialysis. Here we present a case of a 47-year-old female patient with treatment-refractory Crohn's disease on hemodialysis. In this patient, treatment with the anti-IL-12/23 receptor antibody ustekinumab was effective in inducing and maintaining remission while being safe in administering throughout hemodialysis.

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抗il -12/23治疗难治性克罗恩病在血液透析患者中的缓解:1例报告

克罗恩病是一种反复发作的慢性肠道炎症性疾病，在世界各地的患病率越来越高。生物疗法目前广泛使用，并已被证明安全有效地治疗中重度克罗恩病。然而，当代文献中关于这些药物在接受血液透析的终末期肾病患者中的应用的信息很少。在这里我们提出一个47岁的女性患者治疗难治性克罗恩病的血液透析。在该患者中，使用抗il -12/23受体抗体ustekinumab治疗在诱导和维持缓解方面是有效的，同时在整个血液透析过程中是安全的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.