Glymphatic system dysfunction in restless legs syndrome: evidenced by diffusion tensor imaging along the perivascular space.

IF 5.3 2区医学 Q1 CLINICAL NEUROLOGY

Sleep Pub Date : 2023-11-08 DOI:10.1093/sleep/zsad239

Kang Min Park, Keun Tae Kim, Dong Ah Lee, Gholam K Motamedi, Yong Won Cho

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引用次数: 0

Abstract

Study objectives: There is growing evidence pointing at glymphatic system dysfunction in diseases with circadian disruption, such as sleep disorders. Lower diffusivity in the direction of perivascular space has been shown in several neurological and sleep-related disorders; however, its role in restless legs syndrome (RLS) is unclear. We hypothesized that similarly, in RLS the diffusivity in glymphatic system is decreased. Here, we aimed to evaluate glymphatic system functionality in patients with RLS, compare it to healthy controls, and analyze the correlation between its function and clinical characteristics.

Methods: Sixty-nine patients with primary RLS and 51 healthy controls were recruited at a tertiary hospital. All participants underwent diffusion tensor imaging (DTI) and magnetic resonance imaging (MRI) using a 3T MRI scanner, and the DTI along the perivascular space (DTI-ALPS) index was calculated using DTI data. We compared the DTI-ALPS index between the patients with RLS and healthy controls. We also conducted the correlation analysis between the DTI-ALPS index and clinical characteristics, including age, age of onset, symptom duration, and RLS severity.

Results: DTI-ALPS index differed significantly between the patients with RLS and healthy controls; the DTI-ALPS index in the patients with RLS was lower than that in the healthy controls (1.48 vs. 0.60, p = 0.008). There was no significant correlation between the DTI-ALPS index and clinical characteristics.

Conclusion: A significantly lower DTI-ALPS index in patients with RLS suggests that the glymphatic system function is impaired in patients with RLS.

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不宁腿综合征的淋巴系统功能障碍:沿血管周围间隙扩散张量成像证明。

研究目的:越来越多的证据表明，淋巴系统功能障碍与昼夜节律紊乱的疾病有关，如睡眠障碍。在一些神经和睡眠相关疾病中，血管周围空间方向的低弥漫性已被证实;然而，它在不宁腿综合征(RLS)中的作用尚不清楚。我们同样假设，在RLS中，淋巴系统的弥散性降低。在此，我们旨在评估RLS患者的淋巴系统功能，将其与健康对照进行比较，并分析其功能与临床特征之间的相关性。方法:在某三级医院招募69例原发性RLS患者和51例健康对照者。所有参与者均使用3T MRI扫描仪进行弥散张量成像(DTI)和磁共振成像(MRI)，并利用DTI数据计算沿血管周围间隙的DTI (DTI- alps)指数。我们比较了RLS患者与健康对照者的DTI-ALPS指数。我们还对DTI-ALPS指数与年龄、发病年龄、症状持续时间、RLS严重程度等临床特征进行了相关性分析。结果:RLS患者的DTI-ALPS指数与健康对照组有显著差异;RLS患者DTI-ALPS指数低于健康对照组(1.48 vs. 0.60, p = 0.008)。DTI-ALPS指数与临床特征无显著相关性。结论:RLS患者DTI-ALPS指数明显降低，提示RLS患者淋巴系统功能受损。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sleep 医学-临床神经学

CiteScore

10.10

自引率

10.70%

发文量

1134

审稿时长

3 months

期刊介绍： SLEEP® publishes findings from studies conducted at any level of analysis, including: Genes Molecules Cells Physiology Neural systems and circuits Behavior and cognition Self-report SLEEP® publishes articles that use a wide variety of scientific approaches and address a broad range of topics. These may include, but are not limited to: Basic and neuroscience studies of sleep and circadian mechanisms In vitro and animal models of sleep, circadian rhythms, and human disorders Pre-clinical human investigations, including the measurement and manipulation of sleep and circadian rhythms Studies in clinical or population samples. These may address factors influencing sleep and circadian rhythms (e.g., development and aging, and social and environmental influences) and relationships between sleep, circadian rhythms, health, and disease Clinical trials, epidemiology studies, implementation, and dissemination research.