Association between smoking and colorectal cancer in Eastern Mediterranean Regional Office (EMRO): A systematic review and meta-analysis.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-07-04 DOI:10.4103/sjg.sjg_163_23

Mohammad-Hossein Keivanlou, Ehsan Amini-Salehi, Soheil Hassanipour, Abinash Mahapatro, Nakka Raghuma, Farahnaz Joukar, Negin Letafatkar, Arman Habibi, Naeim Norouzi, Maryam Sadat Aleali, Mona Javid, Arian Mirdamadi, Fariborz Mansour-Ghanaei

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引用次数: 3

Abstract

Background: Smoking poses a significant risk for colorectal cancer (CRC), considered the third leading reason for cancer-related deaths worldwide. However, there has been limited research on the relationship between smoking and CRC in the Eastern Mediterranean Regional Office (EMRO). Therefore, a meta-analysis was conducted to combine available data and gain a comprehensive understanding of the relationship between smoking and CRC in EMRO.

Methods: Two independent researchers searched PubMed, Scopus, and Web of Science until December 2022. The included studies were checked for risk of bias administering the Newcastle-Ottawa scale. Heterogeneity was evaluated using I2 statistics and the Cochrane test. Publication bias was determined through funnel plot analysis and Egger's regression test. Additionally, a meta-regression analysis explored the impact of a country's Human Development Index (HDI) on the relationship between smoking and CRC.

Results: The final analysis included 26 studies, revealing a significant association between smoking and CRC (OR = 1.40; 95% CI: 1.11 - 1.78; P = 0.004). Moreover, smoking had a more pronounced adverse effect on CRC in countries with higher HDIs compared to those with lower HDIs (OR = 1.30; 95% CI: 0.99 - 1.71; P = 0.054).

Conclusions: Our findings underscore the importance of implementing smoking cessation programs and policies in EMRO countries, as they demonstrate a positive relationship between smoking and the risk of CRC. Furthermore, the results suggest that a country's level of human development may influence the association between smoking and CRC. Further research is needed to investigate this potential connection and develop targeted public health interventions.

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东地中海区域办公室(EMRO)吸烟与结直肠癌之间的关系:一项系统综述和荟萃分析。

背景:吸烟对结直肠癌(CRC)有显著的风险，结直肠癌被认为是全球癌症相关死亡的第三大原因。然而，东地中海区域办事处(EMRO)对吸烟与结直肠癌之间关系的研究有限。因此，我们进行了一项荟萃分析，结合现有数据，全面了解EMRO中吸烟与结直肠癌之间的关系。方法:两名独立研究人员检索PubMed、Scopus和Web of Science，直到2022年12月。采用纽卡斯尔-渥太华量表对纳入的研究进行偏倚风险检查。采用I2统计和Cochrane检验评估异质性。通过漏斗图分析和Egger回归检验确定发表偏倚。此外，荟萃回归分析探讨了一个国家的人类发展指数(HDI)对吸烟与结直肠癌之间关系的影响。结果:最终分析包括26项研究，揭示了吸烟与结直肠癌之间的显著关联(OR = 1.40;95% ci: 1.11 - 1.78;P = 0.004)。此外，与hdi较低的国家相比，在hdi较高的国家，吸烟对结直肠癌的不良影响更为明显(OR = 1.30;95% ci: 0.99 - 1.71;P = 0.054)。结论:我们的研究结果强调了在EMRO国家实施戒烟计划和政策的重要性，因为它们表明吸烟与结直肠癌风险之间存在正相关关系。此外，研究结果表明，一个国家的人类发展水平可能会影响吸烟与结直肠癌之间的关系。需要进一步研究来调查这种潜在联系并制定有针对性的公共卫生干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.