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{"title":"Aging and Heart Failure with Preserved Ejection Fraction.","authors":"Kathryn F Larson, Awais Malik, Frank V Brozovich","doi":"10.1002/cphy.c210035","DOIUrl":null,"url":null,"abstract":"<p><p>Heart failure is a clinical syndrome characterized by the inability of the cardiovascular system to provide adequate cardiac output at normal filling pressures. This results in a clinical syndrome characterized by dyspnea, edema, and decreased exertional tolerance. Heart failure with preserved ejection fraction (HFpEF) is an increasingly common disease, and the incidence of HFpEF increases with age. There are a variety of factors which contribute to the development of HFpEF, including the presence of hypertension, diabetes, obesity, and other pro-inflammatory states. These comorbid conditions result in changes at the biochemical and cell signaling level which ultimately lead to a disease with a great deal of phenotypic heterogeneity. In general, the physiologic dysfunction of HFpEF is characterized by vascular stiffness, increased cardiac filling pressures, pulmonary hypertension, and impaired volume management. The normal and abnormal processes associated with aging serve as an accelerant in this process, resulting in the hypothesis that HFpEF represents a form of presbycardia. In this article, we aim to review the processes importance of aging in the development of HFpEF by examining the disease and its causes from the biochemical to physiologic level. © 2022 American Physiological Society. Compr Physiol 12: 1-10, 2022.</p>","PeriodicalId":10573,"journal":{"name":"Comprehensive Physiology","volume":"12 4","pages":"3813-3822"},"PeriodicalIF":4.2000,"publicationDate":"2022-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comprehensive Physiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/cphy.c210035","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
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Abstract
Heart failure is a clinical syndrome characterized by the inability of the cardiovascular system to provide adequate cardiac output at normal filling pressures. This results in a clinical syndrome characterized by dyspnea, edema, and decreased exertional tolerance. Heart failure with preserved ejection fraction (HFpEF) is an increasingly common disease, and the incidence of HFpEF increases with age. There are a variety of factors which contribute to the development of HFpEF, including the presence of hypertension, diabetes, obesity, and other pro-inflammatory states. These comorbid conditions result in changes at the biochemical and cell signaling level which ultimately lead to a disease with a great deal of phenotypic heterogeneity. In general, the physiologic dysfunction of HFpEF is characterized by vascular stiffness, increased cardiac filling pressures, pulmonary hypertension, and impaired volume management. The normal and abnormal processes associated with aging serve as an accelerant in this process, resulting in the hypothesis that HFpEF represents a form of presbycardia. In this article, we aim to review the processes importance of aging in the development of HFpEF by examining the disease and its causes from the biochemical to physiologic level. © 2022 American Physiological Society. Compr Physiol 12: 1-10, 2022.
老化和心力衰竭与保留射血分数。
心力衰竭是一种临床综合征,其特征是心血管系统不能在正常充盈压力下提供足够的心输出量。这导致以呼吸困难、水肿和运动耐受性降低为特征的临床综合征。保留射血分数心力衰竭(HFpEF)是一种越来越常见的疾病,其发病率随着年龄的增长而增加。导致HFpEF的因素有很多,包括高血压、糖尿病、肥胖和其他促炎状态。这些合并症导致生化和细胞信号水平的变化,最终导致具有大量表型异质性的疾病。一般来说,HFpEF的生理功能障碍的特征是血管僵硬、心脏充盈压力增加、肺动脉高压和容量管理受损。与衰老相关的正常和异常过程在这一过程中起到了促进作用,从而产生了HFpEF代表一种形式的心老的假设。在本文中,我们旨在通过从生化到生理水平的检查疾病及其原因来回顾衰老在HFpEF发展过程中的重要性。©2022美国生理学会。中国生物医学工程学报(英文版),2016,31(1):1-10。
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