求助PDF
{"title":"Pancreatic Islets as a Target of Adipokines.","authors":"Moritz Reiterer, Ankit Gilani, James C Lo","doi":"10.1002/cphy.c210044","DOIUrl":null,"url":null,"abstract":"<p><p>Rising rates of obesity are intricately tied to the type 2 diabetes epidemic. The adipose tissues can play a central role in protection against or triggering metabolic diseases through the secretion of adipokines. Many adipokines may improve peripheral insulin sensitivity through a variety of mechanisms, thereby indirectly reducing the strain on beta cells and thus improving their viability and functionality. Such effects will not be the focus of this article. Rather, we will focus on adipocyte-secreted molecules that have a direct effect on pancreatic islets. By their nature, adipokines represent potential druggable targets that can reach the islets and improve beta-cell function or preserve beta cells in the face of metabolic stress. © 2022 American Physiological Society. Compr Physiol 12:1-27, 2022.</p>","PeriodicalId":10573,"journal":{"name":"Comprehensive Physiology","volume":"12 3","pages":"4039-4065"},"PeriodicalIF":4.2000,"publicationDate":"2022-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comprehensive Physiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/cphy.c210044","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
引用次数: 0
引用
批量引用
Abstract
Rising rates of obesity are intricately tied to the type 2 diabetes epidemic. The adipose tissues can play a central role in protection against or triggering metabolic diseases through the secretion of adipokines. Many adipokines may improve peripheral insulin sensitivity through a variety of mechanisms, thereby indirectly reducing the strain on beta cells and thus improving their viability and functionality. Such effects will not be the focus of this article. Rather, we will focus on adipocyte-secreted molecules that have a direct effect on pancreatic islets. By their nature, adipokines represent potential druggable targets that can reach the islets and improve beta-cell function or preserve beta cells in the face of metabolic stress. © 2022 American Physiological Society. Compr Physiol 12:1-27, 2022.
胰岛作为脂肪因子的靶点。
肥胖率的上升与2型糖尿病的流行有着复杂的联系。脂肪组织通过分泌脂肪因子在预防或引发代谢性疾病中发挥核心作用。许多脂肪因子可能通过多种机制改善外周胰岛素敏感性，从而间接减少β细胞的压力，从而提高其活力和功能。这类影响将不是本文的重点。相反，我们将重点关注对胰岛有直接影响的脂肪细胞分泌分子。就其性质而言，脂肪因子代表了潜在的可药物靶点，可以到达胰岛，改善β细胞功能或在面对代谢应激时保护β细胞。©2022美国生理学会。物理学报(英文版)，2012。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
