Reactive oxygen species trigger inflammasome activation after intracellular microbial interaction

IF 5.1 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Life sciences Pub Date : 2023-10-15 DOI:10.1016/j.lfs.2023.122076

Caio Pupin Rosa , Thiago Caetano Andrade Belo , Natália Cristina de Melo Santos, Evandro Neves Silva, Juciano Gasparotto, Patrícia Paiva Corsetti, Leonardo Augusto de Almeida

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引用次数: 1

Abstract

The intracellular production of reactive oxygen species (ROS), composed of oxygen-reduced molecules, is important not only because of their lethal effects on microorganisms but also due to their potential inflammatory and metabolic regulation properties. The ROS pro-inflammatory properties are associated with the second signal to inflammasome activation, leading to cleaving pro-IL-1β and pro-IL18 before their secretion, as well as gasdermin-D, leading to pyroptosis. Some microorganisms can modulate NLRP3 and AIM-2 inflammasomes through ROS production: whilst Mycobacterium bovis, Mycobacterium kansasii, Francisella novicida, Brucella abortus, Listeria monocytogenes, Influenza virus, Syncytial respiratory virus, Porcine reproductive and respiratory syndrome virus, SARS-CoV, Mayaro virus, Leishmania amazonensis and Plasmodium sp. enhance inflammasome assembly, Hepatitis B virus, Mycobacterium marinum, Mycobacterium tuberculosis, Francisella tularensis and Leishmania sp. disrupt it. This process represents a recent cornerstone in our knowledge of the immunology of intracellular pathogens, which is reviewed in this mini-review.

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活性氧在细胞内微生物相互作用后触发炎性体活化

由氧还原分子组成的活性氧（ROS）在细胞内的产生很重要，这不仅是因为它们对微生物的致命作用，还因为它们潜在的炎症和代谢调节特性。ROS的促炎特性与炎症小体激活的第二个信号有关，导致前IL-1β和前IL-18在分泌前裂解，以及气皮蛋白-D，导致pyroptosis。一些微生物可以通过ROS的产生调节NLRP3和AIM-2炎症小体：而牛分枝杆菌、堪萨斯分枝杆菌、新冠弗朗西斯杆菌、流产布鲁氏菌、单核细胞增多性李斯特菌、流感病毒、合胞呼吸道病毒、猪繁殖和呼吸综合征病毒、严重急性呼吸系统综合征冠状病毒、马亚罗病毒、亚马逊利什曼原虫和疟原虫增强炎症小体组装，乙型肝炎病毒、海洋分枝杆菌、结核分枝杆菌、兔氏弗朗西斯杆菌和利什曼原虫破坏了它。这一过程代表了我们对细胞内病原体免疫学知识的最新基石，本文对此进行了综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Life sciences 医学-药学

CiteScore

12.20

自引率

1.60%

发文量

841

审稿时长

6 months

期刊介绍： Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. The journal emphasizes the understanding of mechanism that is relevant to all aspects of human disease and translation to patients. All articles are rigorously reviewed. The Journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms. Articles that merely report observations are rarely accepted. Recommendations from the Declaration of Helsinki or NIH guidelines for care and use of laboratory animals must be adhered to. Articles should be written at a level accessible to readers who are non-specialists in the topic of the article themselves, but who are interested in the research. The Journal welcomes reviews on topics of wide interest to investigators in the life sciences. We particularly encourage submission of brief, focused reviews containing high-quality artwork and require the use of mechanistic summary diagrams.