[An integrated approach to the treatment of pretibial myxedema based on pulse therapy with prednisolone and electrical neuromyostimulation (FREMS-therapy) in a patient with Graves' disease and thyroid eye disease].

Q4 Medicine
M A Perepelova, E L Zaitseva, E G Bessmertnaya, Ya O Grusha, N Yu Sviridenko, G R Galstyan
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引用次数: 0

Abstract

Graves' disease (GD) is one of the urgent problems of modern endocrinology, characterized by a high frequency, polysystemic damage to the body, a steadily progressive course, diagnostic difficulties, a high degree of disability and often resistance to therapy. The manifestations of the disease include: thyrotoxicosis syndrome with impaired lipid and carbohydrate metabolism, and activation of multiple organ pathology in the form of thyroid eye disease (TED), pretibial myxedema, cardiovascular insufficiency, acropathy, lesions of the nervous, osteoarticular system, and other lesions. The development of multiple organ pathology can have a different sequence, different time intervals and different degrees of severity. Any developments in the direction of clarifying the etiopathogenetic, clinical diagnostic and treatment-rehabilitation measures are of undoubted significance. We present a clinical case of GD, TED and pretibial myxedema, in which an integrated approach was tested in the tactics of treating pretibial myxedema (a combination of pulse therapy with prednisolone and FREMS-therapy), as a result of which positive results were obtained within a short time.

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[一种基于泼尼松龙脉冲治疗和电神经肌肉刺激(FREMS治疗)治疗Graves病和甲状腺眼病患者的胫前粘液水肿的综合方法]。
Graves病(GD)是现代内分泌学的一个紧迫问题,其特点是对身体的多系统损伤频率高,病程稳步进展,诊断困难,残疾程度高,并且经常对治疗产生耐药性。该疾病的表现包括:甲状腺毒症综合征,脂质和碳水化合物代谢受损,多器官病理激活,表现为甲状腺眼病(TED)、颈前粘液水肿、心血管功能不全、肢端病、神经、骨关节系统病变和其他病变。多器官病理学的发展可能有不同的顺序、不同的时间间隔和不同的严重程度。在阐明病因、临床诊断和治疗康复措施方面的任何进展都具有毋庸置疑的意义。我们报告了一例GD、TED和胫前粘液水肿的临床病例,在该病例中,在治疗胫前粘液肿的策略中测试了一种综合方法(泼尼松龙脉冲治疗和FREMS治疗的组合),结果在短时间内获得了阳性结果。
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来源期刊
Problemy endokrinologii
Problemy endokrinologii Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
1.40
自引率
0.00%
发文量
59
期刊介绍: Since 1955 the “Problems of Endocrinology” (or “Problemy Endocrinologii”) Journal publishes timely articles, balancing both clinical and experimental research, case reports, reviews and lectures on pressing problems of endocrinology. The Journal is aimed to the most topical issues of endocrinology: to chemical structure, biosynthesis and metabolism of hormones, the mechanism of their action at cellular and molecular level; pathogenesis and to clinic of the endocrine diseases, new methods of their diagnostics and treatment. The Journal: features original national and foreign research articles, reflecting world endocrinology development; issues thematic editions on specific areas; publishes chronicle of major international congress sessions and workshops on endocrinology, as well as state-of-the-art guidelines; is intended for scientists, endocrinologists diabetologists and specialists of allied trade, general practitioners, family physicians and pediatrics.
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