Residual Dialkyl Phosphate Metabolite Concentrations of Organophosphate Pesticides Among Indian Farmworkers: Implication of Exposure and Hazard Assessment.

IF 2.3 4区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Journal of Occupational and Environmental Medicine Pub Date : 2023-11-01 Epub Date: 2023-09-02 DOI:10.1097/JOM.0000000000002960

Summaiya Lari, Arun Pandiyan, Janardhan Vanka, Babban Jee, Praveen Yamagani, Senthil Balakrishnan Kumar, Mohan Naidu, Padmaja Jonnalagadda

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引用次数: 0

Abstract

Objective: Biomonitoring of urinary dialkyl phosphate (DAP) metabolites, a sensitive biomarker to assess pesticides exposure and also to study the impact of the use of personal protective equipment (PPE).

Methods: A preintervention-postintervention study to biomonitor dimethylphosphate, diethylphosphate, diethylthiophosphate, and diethyl-dithiophosphate using liquid chromatography with tandem mass spectrometry among Indian farmworkers (n = 120).

Results: Dimethylphosphate was detected in all samples at a mean concentration of 74.91 μg · L -1 (17.616 μg · g -1 creatinine), whereas diethylthiophosphate and diethyl-dithiophosphate were detected in 88% and 82% of samples, respectively, among farmworkers who adopted unsafe pesticide-handling practices. Intervention studies showed a significant reduction in the urinary DAP metabolites detected among the farmworkers using PPE provided to them ( P < 0.01).

Conclusions: Study confirms the exposure to pesticides among farmworkers and highlights the importance of the use of PPE to minimize exposure.

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印度农场工人中有机磷农药残留二烷基磷酸酯代谢产物浓度：暴露和危害评估的意义。

目的：对尿磷酸二烷基酯（DAP）代谢产物进行生物监测，DAP是一种敏感的生物标志物，用于评估农药暴露情况，并研究使用个人防护装备（PPE）的影响，结果：在所有样本中检测到二甲基磷酸盐，平均浓度为74.91μg·L-1（17.616μg·g-1肌酸酐），而在88%和82%的样本中分别检测到二乙基硫代磷酸盐和二乙基二硫代磷酸盐，在采用不安全农药处理方法的农场工人中。干预研究显示，在使用提供给他们的个人防护装备的农场工人中，检测到的尿DAP代谢产物显著减少（P<0.01）。结论：研究证实了农场工人接触农药的情况，并强调了使用个人防护装备以尽量减少接触的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Occupational and Environmental Medicine 医学-公共卫生、环境卫生与职业卫生

CiteScore

4.20

自引率

9.40%

发文量

402

审稿时长

3-8 weeks

期刊介绍： Journal of Occupational and Environmental Medicine is an indispensable guide to good health in the workplace for physicians, nurses, and researchers alike. In-depth, clinically oriented research articles and technical reports keep occupational and environmental medicine specialists up-to-date on new medical developments in the prevention, diagnosis, and rehabilitation of environmentally induced conditions and work-related injuries and illnesses.