Genetic polymorphisms effect on cyclophosphamide's tolerability and clinical efficacy in Egyptian patients with lupus nephritis.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-10-01 Epub Date: 2023-08-24 DOI:10.1097/FPC.0000000000000506

Nermeen N Abuelsoud, Engy M El Khateeb

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引用次数: 0

Abstract

Objectives: Many studies were conducted to determine the association between genetic polymorphisms in CYP2B6 c.516G>T and cyclophosphamide (CYC) efficacy or toxicity, no studies were focused on both clinical efficacy and toxicity of CYC. This study aimed to investigate the relationship between the CYP2B6 c.516G>T polymorphism (rs 3745274) and 17 different parameters related to CYC efficacy and tolerability in Egyptian patients with lupus nephritis (LN).

Methods: A prospective cohort study on 142 LN patients with a mean age of 36.26 was conducted at Kasr Al Ainy School of Medicine, Cairo University, Egypt after the exclusion of 14 patients due to receiving an interacting medication with CYC. All clinical parameters related to CYC efficacy or toxicity were recorded and compared between the different genotypes.

Results: There was a statistically significant difference between different genotypes in 11 out of 13 of the studied efficacy-related parameters. Many of the studied clinical parameters revealed that CYC's efficacy was associated with the presence of the T allele. There was a statistically significant difference between different genotypes in hepatotoxicity, diarrhea, and blood-related toxicities.

Conclusion: To our knowledge, this study is the first study that focused on studying 17 different parameters related to CYC efficacy and tolerability. Our findings paint a picture of the function that CYP2B6 polymorphisms play in Egyptian LN patients. Pre-treatment evaluation of CYP2B6 rs 3745274 may account for some individual differences in treatment response.

查看原文本刊更多论文

遗传多态性对埃及狼疮性肾炎患者环磷酰胺耐受性和临床疗效的影响。

目的：许多研究旨在确定CYP2B6 c.516G>T基因多态性与环磷酰胺（CYC）疗效或毒性之间的关系，但没有研究集中于CYC的临床疗效和毒性。本研究旨在探讨CYP2B6 c.516G>T多态性（rs3745274）与埃及狼疮性肾炎（LN）患者CYC疗效和耐受性相关的17个不同参数之间的关系，埃及因接受与CYC相互作用的药物治疗而排除了14名患者。记录与CYC疗效或毒性相关的所有临床参数，并在不同基因型之间进行比较。结果：在13项研究的疗效相关参数中，有11项在不同基因型之间存在统计学显著差异。许多研究的临床参数表明，CYC的疗效与T等位基因的存在有关。不同基因型在肝毒性、腹泻和血液相关毒性方面存在统计学显著差异。结论：据我们所知，本研究是第一项集中研究与CYC疗效和耐受性相关的17个不同参数的研究。我们的研究结果描绘了CYP2B6多态性在埃及LN患者中的作用。CYP2B6 rs 3745274的治疗前评估可能解释了治疗反应的一些个体差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.