Cost-effectiveness of genetic-based screening strategies for maturity-onset diabetes of the young.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-07-01 Epub Date: 2023-09-11 DOI:10.2217/pme-2023-0023

Gábor Kovács, Dávid Nagy, László Szilberhorn, Tamás Zelei, Zsolt Gaál, Heleen Vellekoop, Simone Huygens, Matthijs Versteegh, Maureen Rutten-van Mölken, Rositsa Koleva-Kolarova, Apostolos Tsiachristas, Sarah Wordsworth, Balázs Nagy

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引用次数: 2

Abstract

Maturity-onset diabetes of the young (MODY) is often misdiagnosed as Type I or II diabetes. This study was designed to assess the cost-effectiveness of MODY screening strategies in Hungary, which included a recent genetic test compared with no routine screening for MODY. A simulation model that combined a decision tree and an individual-level Markov model was constructed to assess the costs per quality-adjusted life year of screening strategies. Stratifying patients based on age and insulin treatment followed by a risk assessment questionnaire, a laboratory test and genetic testing was the most cost-effective strategy, saving EUR 12 and generating 0.0047 quality-adjusted life years gained per screened patient. This screening strategy could be considered for reimbursement, especially in countries with limited resources.

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基于基因的筛查策略对年轻人成熟期糖尿病的成本效益。

青年期成熟期糖尿病（MODY）常被误诊为I型或II型糖尿病。这项研究旨在评估匈牙利MODY筛查策略的成本效益，其中包括最近的一项基因测试，与没有常规筛查的MODY相比。构建了一个结合决策树和个体水平马尔可夫模型的模拟模型，以评估筛选策略的每个质量调整生命年的成本。根据年龄和胰岛素治疗对患者进行分层，然后进行风险评估问卷、实验室检测和基因检测，这是最具成本效益的策略，为每位筛查患者节省了12欧元，并增加了0.0047个质量调整后的生命年数。可以考虑采用这种筛选策略进行补偿，特别是在资源有限的国家。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.