Elevated HSP70 and HSP90 as Predictive Markers of Immune Activation and Lung Injury in SARS-COV-2 Disease.

IF 1.1 4区医学 Q4 IMMUNOLOGY

Iranian Journal of Immunology Pub Date : 2023-09-01 DOI:10.22034/iji.2023.97202.2488

Zivar Zangeneh, Gholamreza Khamisipour

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引用次数: 0

Abstract

Background: Heat shock proteins (HSPs) are involved in innate and adaptive immune responses, especially inflammatory responses due to immune cell activation. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was one of the most important causes of death in the recent pandemic. Increased cellular stress and excessive inflammation are common in coronavirus disease-19 (COVID-19), although the underlying mechanisms are still poorly understood.

Objective: To evaluate the relationship between HSP and the pathological effects of COVID-19.

Methods: A group of 107 patients was categorized to two populations (mild and severe) based on their chest high-resolution computed tomography (HRCT) results. The HSP70, HSP90 alpha, and serum levels of C-reactive protein (CRP) were measured by enzyme-linked immunosorbent assay (ELISA). Lactate dehydrogenase (LDH), and creatine phosphokinase (CPK) were measured by the automated analyzer.

Results: Our data showed increased levels of HSP70 and HSP90 in patients with COVID-19. The HSPs levels were elevated in the severe group compared to the mild group. This study demonstrated a positive correlation between both elevated levels of HSP70, HSP90, and HRCT grade and also a positive correlation with CRP and CPK in the severe group.

Conclusion: HSP90 and HSP70 contribute to excessive immune responses and cytokine storms. They may serve as prognostic serum markers for COVID-19 lung injury. Additionally, they are candidates for anti-inflammatory therapy.

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HSP70和HSP90升高作为SARS-COV-2疾病中免疫激活和肺损伤的预测标志物

背景：热休克蛋白（HSPs）参与先天性和适应性免疫反应，特别是免疫细胞活化引起的炎症反应。严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）是最近大流行病中最重要的死亡原因之一。在冠状病毒病-19（COVID-19）中，细胞应激增加和过度炎症也很常见，但其潜在机制仍不甚明了：评估 HSP 与 COVID-19 病理效应之间的关系：方法：根据胸部高分辨率计算机断层扫描（HRCT）结果，将一组 107 例患者分为轻度和重度两类。通过酶联免疫吸附试验（ELISA）测量 HSP70、HSP90 alpha 和血清中 C 反应蛋白（CRP）的水平。乳酸脱氢酶（LDH）和肌酸磷酸激酶（CPK）由自动分析仪测定：结果：我们的数据显示，COVID-19 患者体内的 HSP70 和 HSP90 水平升高。与轻度组相比，重度组的 HSPs 水平升高。本研究表明，HSP70、HSP90 水平升高与 HRCT 分级呈正相关，在重度组中还与 CRP 和 CPK 呈正相关：结论：HSP90 和 HSP70 会导致过度的免疫反应和细胞因子风暴。结论：HSP90 和 HSP70 会导致过度的免疫反应和细胞因子风暴，可作为 COVID-19 肺损伤的预后血清标志物。此外，它们还是抗炎治疗的候选指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Iranian Journal of Immunology Medicine-Immunology and Allergy

CiteScore

1.60

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： The Iranian Journal of Immunology (I.J.I) is an internationally disseminated peer-reviewed publication and publishes a broad range of experimental and theoretical studies concerned with all aspects of immunology.