Agreement between incisional and excisional biopsies for hormone receptors and her2 in breast cancer.

IF 0.5 4区医学 Q4 SURGERY

Cirugia Y Cirujanos Pub Date : 2023-01-01 DOI:10.24875/CIRU.22000197

Fernando Candanedo-Gonzalez, Juan C Cordova-Ramón, Jessica Smeke-Smeke, Wilfredo Valenzuela-Gonzalez, Armando Gamboa-Dominguez

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引用次数: 0

Abstract

Introduction: Breast cancer is the leading cause of cancer mortality in Mexican women.

Objective: The objective of the study was to identify concordances among core needle biopsy (CNB) and excisional biopsies (EB) regarding diagnosis, hormonal receptors (HR), and human epidermal growth factor receptor 2 (Her2).

Materials and methods: Core number, demographic data, histological type, and treatment were documented for each sample. Reported HR and Her2 score from both samples were compiled.

Results: 70 women with both CNB/EB were included. Median age was 58 (36-87) years; initial diagnosis in CNB were invasive ductal 56 (80%), lobular 10 (14%), and mixed 4 (6%) carcinomas. Diagnostic agreement among CNB and EB was of 97%, k = 0.65. A concordance of 92% (k = 0.75), 75% (k = 0.26), and 67% (k = 0.46) was observed for estrogen receptors, progesterone receptors, and Her2 determinations, and positive predictive values in CNB were 0.96, 0.89, and 0.44, respectively.

Conclusion: HR and Her2 concordances using manual-immunohistochemistry (IHC) were found within the range of values obtained using automatized-IHC. When compared to tumor heterogeneity, technical/reading errors contribute more to discordances.

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乳腺癌中激素受体和her2的切口和切除活检的一致性。

简介:乳腺癌是墨西哥妇女癌症死亡的主要原因。目的:本研究的目的是确定核心针活检(CNB)和切除活检(EB)在诊断、激素受体(HR)和人表皮生长因子受体2 (Her2)方面的一致性。材料和方法:记录每个样本的核心编号、人口统计学数据、组织学类型和治疗方法。对两个样本报告的HR和Her2评分进行汇总。结果:70名同时患有CNB/EB的女性入选。中位年龄为58(36-87)岁;CNB的初步诊断为浸润性导管癌56例(80%)，小叶癌10例(14%)，混合性癌4例(6%)。CNB与EB的诊断一致性为97%，k = 0.65。雌激素受体、孕激素受体和Her2检测的一致性分别为92% (k = 0.75)、75% (k = 0.26)和67% (k = 0.46)， CNB阳性预测值分别为0.96、0.89和0.44。结论:人工免疫组化(IHC)的HR和Her2一致性在自动免疫组化(IHC)得到的值范围内。与肿瘤异质性相比，技术/读取错误更容易导致不一致。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cirugia Y Cirujanos 医学-外科

CiteScore

0.90

自引率

20.00%

发文量

207

审稿时长

6-12 weeks

期刊介绍： Cirugía y Cirujanoses exponente del desarrollo académico, científico, médico, quirúrgico y tecnológico en materia de salud en México y en el ámbito internacional. Es una revista bimestral, open access, revisada por pares, que publica en español y en inglés (traducido sin coste para los autores) artículos científicos originales, casos clínicos, artículos de revisión de interés general y cartas al editor. Los artículos se seleccionan y publican siguiendo un riguroso análisis, de acuerdo con los estándares internacionalmente aceptados. Sus espacios están abiertos a los académicos, así como a todo miembro de la comunidad médica que manifieste interés por utilizar este foro para publicar sus trabajos.