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{"title":"The Role of B Lymphocyte Subsets in Adipose Tissue Development, Metabolism, and Aging.","authors":"Nicole C Fernandez, Kosaku Shinoda","doi":"10.1002/cphy.c220006","DOIUrl":null,"url":null,"abstract":"<p><p>Adipose tissue contains resident B lymphocytes (B cells) with varying immune functions and mechanisms, depending on the adipose depot type and location. The heterogeneity of B cells and their functions affect the immunometabolism of the adipose tissue in aging and age-associated metabolic disorders. B cells exist in categorizations of subsets that have developmental or phenotypic differences with varying functionalities. Subsets can be categorized as either protective or pathogenic depending on their secretion profile or involvement in metabolic maintenance. In this article, we summarized recent finding on the B cell heterogeneity and discuss how we can utilize our current knowledge of adipose resident B lymphocytes for potential treatment for age-associated metabolic disorders. © 2022 American Physiological Society. Compr Physiol 12: 1-13, 2022.</p>","PeriodicalId":10573,"journal":{"name":"Comprehensive Physiology","volume":"12 4","pages":"4133-4145"},"PeriodicalIF":4.2000,"publicationDate":"2022-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comprehensive Physiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/cphy.c220006","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
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Abstract
Adipose tissue contains resident B lymphocytes (B cells) with varying immune functions and mechanisms, depending on the adipose depot type and location. The heterogeneity of B cells and their functions affect the immunometabolism of the adipose tissue in aging and age-associated metabolic disorders. B cells exist in categorizations of subsets that have developmental or phenotypic differences with varying functionalities. Subsets can be categorized as either protective or pathogenic depending on their secretion profile or involvement in metabolic maintenance. In this article, we summarized recent finding on the B cell heterogeneity and discuss how we can utilize our current knowledge of adipose resident B lymphocytes for potential treatment for age-associated metabolic disorders. © 2022 American Physiological Society. Compr Physiol 12: 1-13, 2022.
B淋巴细胞亚群在脂肪组织发育、代谢和衰老中的作用。
根据脂肪储存的类型和位置，脂肪组织含有具有不同免疫功能和机制的常驻B淋巴细胞(B细胞)。B细胞的异质性及其功能影响衰老和年龄相关代谢紊乱中脂肪组织的免疫代谢。B细胞以亚群的形式存在，这些亚群具有发育或表型差异，具有不同的功能。亚群可分为保护性或致病性，这取决于它们的分泌情况或参与代谢维持。在这篇文章中，我们总结了最近关于B细胞异质性的发现，并讨论了我们如何利用我们目前对脂肪驻留B淋巴细胞的知识来治疗与年龄相关的代谢紊乱。©2022美国生理学会。中国生物医学工程学报(英文版)，2016,31(1):1-13。
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