Expression and Significance of MTA2 and CPNE1 in Cervical Squamous Cell Carcinoma.

IF 1.3 4区 医学 Q3 ANATOMY & MORPHOLOGY
Lixin Wang, Gang Chen, Chen Zhou, Chao Wu, Jingui Jiang
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引用次数: 0

Abstract

The aim of this study was to investigate the expression and clinical significance of MTA2 and CPNE1 proteins in cervical squamous cell carcinoma. In this study, high-risk human papillomavirus (HPV) typing was performed on cervical cancer tissues. Reverse transcription polymerase chain reaction and immunochemical EliVision method were used to examine the expressions of MTA2 and CPNE1 in the cervix, and their relationship with clinicopathologic features. We found that it is mainly distributed in these types, namely HPV-16 (23.8%), HPV-18 (20.9%), HPV-53 (17.1%), HPV-52 (15.5%), HPV-82 (11.7%), HPV-56 (10.8%). The expressions of MTA2 and CPNE1 in cervical squamous cell carcinoma tissues were significantly higher than those in normal tissues ( P <0.01). The expressions of MTA2 and CPNE1 were correlated with FIGO stage, degree of differentiation, and lymph node metastasis of cervical cancer ( P <0.05), but not with the patient's age ( P >0.05). The rank correlation coefficient of MTA2 and CPNE1 protein expression in cervical squamous cell carcinoma was 0.668 ( P <0.01), and the 2 expressions were positively correlated. MTA2 and CPNE1 are closely related to the occurrence and development of cervical squamous cell carcinoma and may play a synergistic role in the evolution of cervical squamous cell carcinoma.

MTA2和CPNE1在宫颈鳞状细胞癌中的表达及意义。
本研究旨在探讨MTA2和CPNE1蛋白在宫颈鳞状细胞癌中的表达及其临床意义。本研究对癌症宫颈组织进行高危型人乳头瘤病毒(HPV)分型。采用逆转录聚合酶链反应和免疫化学EliVision方法检测MTA2和CPNE1在宫颈中的表达及其与临床病理特征的关系。我们发现它主要分布在这些类型中,即HPV-16(23.8%)、HPV-18(20.9%)、HPV-53(17.1%)、HPV-52(15.5%)、,HPV-56(10.8%),MTA2和CPNE1在宫颈鳞状细胞癌组织中的表达明显高于正常组织(P<0.05),MTA2/CPNE1在宫颈鳞癌中的表达等级相关系数为0.668(P<0.01)
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来源期刊
Applied Immunohistochemistry & Molecular Morphology
Applied Immunohistochemistry & Molecular Morphology ANATOMY & MORPHOLOGY-MEDICAL LABORATORY TECHNOLOGY
CiteScore
3.20
自引率
0.00%
发文量
153
期刊介绍: ​Applied Immunohistochemistry & Molecular Morphology covers newly developed identification and detection technologies, and their applications in research and diagnosis for the applied immunohistochemist & molecular Morphologist. Official Journal of the International Society for Immunohistochemisty and Molecular Morphology​.
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